Neuroprotective effects of sildenafil in experimental spinal cord injury in rabbits

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dc.contributor.authorKara, Hasan
dc.contributor.authorDegirmenci, Selim
dc.contributor.authorAk, Ahmet
dc.contributor.authorBayir, Aysegul
dc.contributor.authorKayis, Seyit Ali
dc.contributor.authorUyar, Mehmet
dc.contributor.authorAkinci, Murat
dc.date.accessioned2020-03-26T19:06:25Z
dc.date.available2020-03-26T19:06:25Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractNeuroprotective agents such as methylprednisolone and sildenafil may limit damage after spinal cord injury. We evaluated the effects of methylprednisolone and sildenafil on biochemical and histologic changes after spinal cord injury in a rabbit model. Female New Zealand rabbits (32 rabbits) were allocated to 4 equal groups: laminectomy only (sham control) or laminectomy and spinal trauma with no other treatment (trauma control) or treatment with either methylprednisolone or sildenafil. Gelsolin and caspase-3 levels in cerebrospinal fluid and plasma were determined, and spinal cord histology was evaluated at 24 hours after trauma. There were no differences in mean cerebrospinal fluid or plasma levels of caspase-3 between the groups or within the groups from 0 to 24 hours after injury. From 0 to 24 hours after trauma, mean cerebrospinal fluid gelsolin levels significantly increased in the sildenafil group and decreased in the sham control and the trauma control groups. Mean plasma gelsolin level was significantly higher at 8 and 24 hours after trauma in the sildenafil than other groups. Histologic examination indicated that general structural integrity was better in the methylprednisolone in comparison with the trauma control group. General structural integrity, leptomeninges, white and grey matter hematomas, and necrosis were significantly improved in the sildenafil compared with the trauma control group. Caspase-3 levels in the cerebrospinal fluid and blood were not increased but gelsolin levels were decreased after spinal cord injury in trauma control rabbits. Sildenafil caused an increase in gelsolin levels and may be more effective than methylprednisolone at decreasing secondary damage to the spinal cord.en_US
dc.description.sponsorshipSelcuk Universitesi Bilimsel Arastirma Projeleri KoordinatorluguSelcuk Universityen_US
dc.description.sponsorshipThis study was supported by "Selcuk Universitesi Bilimsel Arastirma Projeleri Koordinatorlugu".en_US
dc.identifier.doi10.17305/bjbms.2015.1.119en_US
dc.identifier.endpage44en_US
dc.identifier.issn1512-8601en_US
dc.identifier.issn1840-4812en_US
dc.identifier.issue1en_US
dc.identifier.pmid25725143en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://dx.doi.org/10.17305/bjbms.2015.1.119
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32353
dc.identifier.volume15en_US
dc.identifier.wosWOS:000351116300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVOen_US
dc.relation.ispartofBOSNIAN JOURNAL OF BASIC MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCaspase-3en_US
dc.subjectgelsolinen_US
dc.subjectmethylprednisoloneen_US
dc.subjectphosphodiesterase type 5en_US
dc.subjecttraumaen_US
dc.titleNeuroprotective effects of sildenafil in experimental spinal cord injury in rabbitsen_US
dc.typeArticleen_US

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