A magnetically separable biocatalyst for resolution of racemic naproxen methyl ester

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dc.contributor.authorOzyilmaz, Elif
dc.contributor.authorSayin, Serkan
dc.date.accessioned2020-03-26T18:41:00Z
dc.date.available2020-03-26T18:41:00Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCandida rugosa lipase (CRL) was encapsulated via the sol-gel method, using 5, 11, 17, 23-tetra-tert-butyl-25,27-bis(2-aminopyridine)carbonylmethoxy-26, 28-dihydroxy-calix[4]arene-grafted magnetic Fe3O4 nanoparticles (Calix-M-E). The catalytic activity of encapsulated lipase (Calix-M-E) was tested both in the hydrolysis of p-nitrophenyl palmitate (p-NPP) and the enantioselective hydrolysis of racemic naproxen methyl ester. The present study demonstrated that the calixarene-based compound has the potential to enhance both reaction rate and enantioselectivity of the lipase-catalyzed hydrolysis of racemic naproxen methyl ester. The encapsulated lipase (Calix-M-E) had great catalytic activity and enantioselectivity (E > 400), as well as remarkable reusability as compared to the encapsulated lipase without supports (E = 137) for S-Naproxen.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University, Konya, Turkey (BAP)Selcuk Universityen_US
dc.description.sponsorshipWe thank the Scientific Research Foundation of Selcuk University, Konya, Turkey (BAP) for financial support of this work.en_US
dc.identifier.doi10.1007/s00449-013-0941-3en_US
dc.identifier.endpage1806en_US
dc.identifier.issn1615-7591en_US
dc.identifier.issn1615-7605en_US
dc.identifier.issue11en_US
dc.identifier.pmid23525833en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1803en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00449-013-0941-3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29156
dc.identifier.volume36en_US
dc.identifier.wosWOS:000325772600028en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofBIOPROCESS AND BIOSYSTEMS ENGINEERINGen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNanoparticlesen_US
dc.subjectFe3O4en_US
dc.subjectLipaseen_US
dc.subjectCalixareneen_US
dc.subjectEnantioselectivityen_US
dc.titleA magnetically separable biocatalyst for resolution of racemic naproxen methyl esteren_US
dc.typeArticleen_US

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