Role of the nitric oxide on diazoxide-induced relaxation of the calf cardiac vein and coronary artery during cooling

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dc.contributor.authorAtalik, K. E.
dc.contributor.authorKilic, M.
dc.contributor.authorDogan, N.
dc.date.accessioned2020-03-26T17:40:03Z
dc.date.available2020-03-26T17:40:03Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effects of cooling (to 28 degrees C) on the vasodilation induced by diazoxide (10(-9)-3 x 10(-4) m) on carbachol-pre-contracted calf cardiac vein and coronary artery and the role of nitric oxide in these effects were analyzed. Diazoxide produced concentration-dependent relaxation of calf cardiac vein and coronary artery rings pre-contracted with carbachol (10(-6) m). During cooling, the pIC(50) values, but not the maximal responses, to diazoxide were significantly lower than at 37 degrees C in both preparations. Cooling to 28 degrees C in the presence of N(G)-nitro-L-arginine methyl ester (10(-4) m) did not modify the effect of temperature both in cardiac vein and coronary artery. These results suggest that cooling-induced changes of diazoxide in calf cardiac vein and coronary artery are independent of nitric oxide.en_US
dc.description.sponsorshipScientific Research Foundation of Selcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipThis study is supported by the Scientific Research Foundation of Selcuk University.en_US
dc.identifier.doi10.1111/j.1472-8206.2009.00671.xen_US
dc.identifier.endpage277en_US
dc.identifier.issn0767-3981en_US
dc.identifier.issue3en_US
dc.identifier.pmid19469805en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1472-8206.2009.00671.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23837
dc.identifier.volume23en_US
dc.identifier.wosWOS:000266598700002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELL PUBLISHING, INCen_US
dc.relation.ispartofFUNDAMENTAL & CLINICAL PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcardiac veinen_US
dc.subjectcoolingen_US
dc.subjectcoronary arteryen_US
dc.subjectdiazoxideen_US
dc.subjectnitric oxideen_US
dc.titleRole of the nitric oxide on diazoxide-induced relaxation of the calf cardiac vein and coronary artery during coolingen_US
dc.typeArticleen_US

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