Pharmacokinetics of enrofloxacin following intravenous and intramuscular administration in Angora rabbits

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dc.contributor.authorElmas, Muammer
dc.contributor.authorUney, Kamil
dc.contributor.authorYazar, Enver
dc.contributor.authorKarabacak, Ayse
dc.contributor.authorTras, Bunyamin
dc.date.accessioned2020-03-26T17:17:52Z
dc.date.available2020-03-26T17:17:52Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe pharmacokinetic behaviour and bioavailability of enrofloxacin (ENR) were determined after single intravenous (iv) and intramuscular (im) administrations of 5 mg/kg bw to six healthy adult Angora rabbits. Plasma ENR concentrations were measured by high performance liquid chromatography. The pharmacokinetic data were best described by a two-compartment open model. ENR pharmacokinetic parameters were similar (p > 0.05) for iv and im administrations in terms of AUC(0-infinity)t(1/2 beta) and MRT. ENR was rapidly (t(1/2a), 0.05 h) and almost completely (F, 87%) absorbed after im injection. In conclusion, the pharmacokinetic properties of ENR following iv and im administration in Angora rabbits are similar to other rabbit breeds, and once or twice daily iv and im administrations of ENR at the dose of 5 mg/kg bw, depending upon the causative pathogen and/or severity of disorders, may be useful in treatment of infectious diseases caused by sensitive pathogens in Angora rabbits. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.rvsc.2006.06.008en_US
dc.identifier.endpage245en_US
dc.identifier.issn0034-5288en_US
dc.identifier.issue2en_US
dc.identifier.pmid16930647en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage242en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.rvsc.2006.06.008
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21523
dc.identifier.volume82en_US
dc.identifier.wosWOS:000244921000017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofRESEARCH IN VETERINARY SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectpharmacokineticsen_US
dc.subjectenrofloxacinen_US
dc.subjectAngora rabbitsen_US
dc.titlePharmacokinetics of enrofloxacin following intravenous and intramuscular administration in Angora rabbitsen_US
dc.typeArticleen_US

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