Comparison of local and systemic alendronate on distraction osteogenesis

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dc.contributor.authorKucuk, Dervishan
dc.contributor.authorAy, Sinan
dc.contributor.authorKara, M. Isa
dc.contributor.authorAvunduk, M. Cihat
dc.contributor.authorGumus, Cesur
dc.date.accessioned2020-03-26T18:13:59Z
dc.date.available2020-03-26T18:13:59Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study compared the effect of systemic and local administration of alendronate on distraction osteogenesis in rabbit mandibles. Thirty New Zealand white rabbits were allocated to 3 groups: 10 rabbits for systemic alendronate; 9 for local alendronate; and 11 as controls. After a 5 day latency period, distraction was performed at a rate of 0.8 mm/day for 9 days via a custom-made distractor. Animals were killed at the end of the consolidation period of 28 days. The distracted mandibles were harvested and evaluated by plain radiography, computed tomography (CT), dual energy X-ray absorptiometry (DEXA), and histomorphometry. Histologically, comparing the systemic and local alendronate groups, there were no statistically significant differences in the bone healing parameters, but each group showed a statistically superior effect over the control group (p < 0.05). Quantitative CT evaluation showed a significant difference mean in the density of the regeneration between experimental and control groups. There was a significant increase in mean bone mineral density in the experimental groups compared with the control group. Histologic, CT, and DEXA analysis demonstrated that using systemic and local alendronate may be effective in accelerating new bone formation in the distraction gap in rabbit mandibles.en_US
dc.description.sponsorshipCumhuriyet UniversityCumhuriyet Universityen_US
dc.description.sponsorshipYes. This study was funded by Scientific Research Project, Cumhuriyet University.en_US
dc.identifier.doi10.1016/j.ijom.2011.08.004en_US
dc.identifier.endpage1400en_US
dc.identifier.issn0901-5027en_US
dc.identifier.issn1399-0020en_US
dc.identifier.issue12en_US
dc.identifier.pmid21945486en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1395en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijom.2011.08.004
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26260
dc.identifier.volume40en_US
dc.identifier.wosWOS:000298723700011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCHURCHILL LIVINGSTONEen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdistraction osteogenesisen_US
dc.subjectmandibleen_US
dc.subjectalendronate sodiumen_US
dc.titleComparison of local and systemic alendronate on distraction osteogenesisen_US
dc.typeArticleen_US

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