Synthesis of new water-soluble phosphonate calixazacrowns and their use as drug solubilizing agents
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Dosyalar
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
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Yayıncı
SPRINGER
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study presents the selective chloromethylation of calix[4](aza)crown ethers 2a-c, using chloromethyl n-octyl ether and SnCl4 in chloroform at room temperature in good yield for the first time. Chloromethylated products 2a-c are used as key intermediates to synthesize new water-soluble p-phosphonato calix[4](aza)crown ethers 5a-c. Liquid-liquid phase extraction and phase solubility studies with poor water soluble drug molecules such as nifedipine, niclosamide and furosemide are performed to evaluate their binding properties. Among the studied drugs, furosemide was the most effectively dissolved drug by p-phosphonato calix[4](aza)crown ethers 5a-c in water.
Açıklama
Anahtar Kelimeler
Calixarene, Chloromethylation, Niclosamide, Furosemide, Nifedipine
Kaynak
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
74
Sayı
01.04.2020
