Synthesis of new water-soluble phosphonate calixazacrowns and their use as drug solubilizing agents

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dc.contributor.authorBayrakçı, Mevlüt
dc.contributor.authorErtul, Şeref
dc.contributor.authorYılmaz, Mustafa
dc.date.accessioned2020-03-26T18:31:30Z
dc.date.available2020-03-26T18:31:30Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study presents the selective chloromethylation of calix[4](aza)crown ethers 2a-c, using chloromethyl n-octyl ether and SnCl4 in chloroform at room temperature in good yield for the first time. Chloromethylated products 2a-c are used as key intermediates to synthesize new water-soluble p-phosphonato calix[4](aza)crown ethers 5a-c. Liquid-liquid phase extraction and phase solubility studies with poor water soluble drug molecules such as nifedipine, niclosamide and furosemide are performed to evaluate their binding properties. Among the studied drugs, furosemide was the most effectively dissolved drug by p-phosphonato calix[4](aza)crown ethers 5a-c in water.en_US
dc.description.sponsorshipS.U. Research FoundationSelcuk University [BAP: 10101016]en_US
dc.description.sponsorshipThis study is part of the PhD Thesis of Mevlut Bayrakci and the authors gratefully would like to thank S.U. Research Foundation (BAP: 10101016) for financial support.en_US
dc.identifier.doi10.1007/s10847-012-0115-yen_US
dc.identifier.endpage303en_US
dc.identifier.issn1388-3127en_US
dc.identifier.issn1573-1111en_US
dc.identifier.issue01.04.2020en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage293en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10847-012-0115-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28461
dc.identifier.volume74en_US
dc.identifier.wosWOS:000306946700029en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCalixareneen_US
dc.subjectChloromethylationen_US
dc.subjectNiclosamideen_US
dc.subjectFurosemideen_US
dc.subjectNifedipineen_US
dc.titleSynthesis of new water-soluble phosphonate calixazacrowns and their use as drug solubilizing agentsen_US
dc.typeArticleen_US

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