Effect of Chronic Regular Exercise on Serum Ischemia-Modified Albumin Levels and Oxidative Stress in Type 2 Diabetes Mellitus

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dc.contributor.authorKurban, Sevil
dc.contributor.authorMehmetoglu, Idris
dc.contributor.authorYerlikaya, Humeyra F.
dc.contributor.authorGonen, Sait
dc.contributor.authorErdem, Sami
dc.date.accessioned2020-03-26T18:14:13Z
dc.date.available2020-03-26T18:14:13Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives. Our aim was to determine the effect of chronic regular exercise on ischemia-modified albumin (IMA) levels and oxidative stress in type 2 diabetes mellitus (DM). Design and methods. Sixty patients with type 2 DM were randomly divided into two groups as exercise (17 M, 13 F) and non-exercise (12 M, 18 F) groups, each consisting of 30 patients. The exercise group underwent a 3-month aerobic regular exercise consisting of moderate-intensity power walking. The non-exercise subjects remained sedentary throughout the study period. Serum total antioxidant status (TAS), total oxidant status (TOS), and IMA levels of the groups were determined at baseline and 3 months later. Results. There was no significant change in TOS and IMA levels of exercise group but TAS levels were significantly increased (p < 0.05). Also, postexercise systolic (p < 0.001) and diastolic (p < 0.05) blood pressures of the exercise group were significantly lower than the baseline values. In addition, there was no significant change in TAS and TOS levels of the non-exercise group; however, IMA levels were significantly increased (p < 0.01). Conclusion. We have shown, for the first time, that exercise prevents increase in IMA levels in type 2 DM which might have resulted from increased levels of TAS and reduces the risk of ischemia in these patients. These findings show that chronic exercise is beneficial in the prevention of oxidative stress in patients with type 2 DM as documented by decreased IMA levels.en_US
dc.identifier.doi10.3109/07435800.2011.566236en_US
dc.identifier.endpage123en_US
dc.identifier.issn0743-5800en_US
dc.identifier.issn1532-4206en_US
dc.identifier.issue3en_US
dc.identifier.pmid21736494en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage116en_US
dc.identifier.urihttps://dx.doi.org/10.3109/07435800.2011.566236
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26351
dc.identifier.volume36en_US
dc.identifier.wosWOS:000292568300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofENDOCRINE RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiabetes mellitusen_US
dc.subjectChronic regular exerciseen_US
dc.subjectIschemia-modified albuminen_US
dc.subjectTotal antioxidant statusen_US
dc.subjectTotal oxidant statusen_US
dc.titleEffect of Chronic Regular Exercise on Serum Ischemia-Modified Albumin Levels and Oxidative Stress in Type 2 Diabetes Mellitusen_US
dc.typeArticleen_US

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