Pharmacological Mechanism of Topical Lodoxamide Treatment in Vernal Keratoconjunctivitis: a Flow-Cytometric Study

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dc.contributor.authorAvunduk, Avni Murat
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorDayanır, Volkan
dc.contributor.authorTekelioğlu, Yavuz
dc.contributor.authorDayıoğlu, Yavuz Selim
dc.date.accessioned2020-03-26T16:26:16Z
dc.date.available2020-03-26T16:26:16Z
dc.date.issued1998
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the possible effect of lodoxamide 0.1% ophthalmic solution (LOS) on tear T lymphocytes, especially Th2 (T helper 2 subgroup of helper T lymphocytes), in the tear specimens of patients with vernal keratoconjunctivitis (VKC) and to explore the mechanism of the anti-allergic effect of this drug. Twenty-eight active VKC patients were randomly divided into two groups each containing 14 patients. We obtained tear samples from all patients at the beginning of the study. LOS was prescribed to the study group (group A), but the controls (group B) received placebo over the course of 6 weeks. Tear samples were also collected from all patients following a 6-week course of treatment with either LOS or placebo. The percentages of Th1, Th2 and Th cells in the tear samples were measured by using a flow-cytometric technique and the results were compared to each other by using Wilcoxon matched-pairs signed-rank and Mann-Whitney U tests. We found that LOS treatment decreased the percentages of Th2 and Th cells in the tears of group A patients, while placebo had no effect on these values, Th1 cell count in the tears of both groups of patients did not show any significant change between the pre-and posttreatment stages, Our data suggest that LOS exerts, at least, some part of its anti-allergic effect via decreasing the Th2 cell number in the tears of VKC patients.en_US
dc.identifier.citationAvunduk, M. C., Avunduk, A. M., Dayanır, V., Tekelioğlu, Y., Dayıoğlu, Y. S., (1998). Pharmacological Mechanism of Topical Lodoxamide Treatment in Vernal Keratoconjunctivitis: a Flow-Cytometric Study. Ophthalmic Research, 30(1), 37-43.
dc.identifier.endpage43en_US
dc.identifier.issn0030-3747en_US
dc.identifier.issue1en_US
dc.identifier.pmid9483586en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16783
dc.identifier.volume30en_US
dc.identifier.wosWOS:000071783100005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAvunduk, Mustafa Cihat
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofOphthalmic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectVernal Keratoconjunctivitisen_US
dc.subjectFlow Cytometryen_US
dc.subjectHelper T Lymphocyteen_US
dc.subjectT Helper 2 Lymphocyteen_US
dc.subjectLodoxamide Treatmenten_US
dc.titlePharmacological Mechanism of Topical Lodoxamide Treatment in Vernal Keratoconjunctivitis: a Flow-Cytometric Studyen_US
dc.typeArticleen_US

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