Breastmilk ghrelin, leptin, and fat levels changing foremilk to hindmilk: is that important for self-control of feeding?

dc.contributor.authorKaratas, Zehra
dc.contributor.authorAydogdu, Sultan Durmus
dc.contributor.authorDinleyici, Ener Cagri
dc.contributor.authorColak, Omer
dc.contributor.authorDogruel, Nesrin
dc.date.accessioned2020-03-26T18:13:53Z
dc.date.available2020-03-26T18:13:53Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the changes in the ghrelin, leptin, and fat levels in the foremilk and hindmilk and the possible relationship between these levels with the age and growth of term healthy infants. Sixty-two babies were subdivided (according to their nutrition) into breastfed (BF), formula-fed (FF), and BF plus FF (BF + FF) groups. The total and active ghrelin and tryglyceride levels and the total cholesterol levels in the foremilk and hindmilk were studied at the first and second visits (mean of the second and fifth months, respectively). At both visits, the total and active ghrelin and the total cholesterol levels were lower in the hindmilk than in the foremilk. However, the triglyceride levels were higher in the hindmilk than in the foremilk (p < 0.001). The leptin levels were also higher in the hindmilk, but this difference was not statistically significant. At the second visit, the mean total foremilk ghrelin (p < 0.01), leptin (p < 0.05), tryglyceride (p < 0.001), and cholesterol (p < 0.01) levels in the BF group were decreased compared with the levels at the first visit, whereas the active ghrelin levels increased (p < 0.001). At the second visit, we observed a 3.5% increase in the body mass index in BF infants, a 14.6% increase in FF infants, and an 11.8% increase in BF + FF infants (p < 0.01). The foremilk leptin levels were lower in the BF + FF group than in the BF group at both visits. In conclusion, at the first and second visits, the decreased ghrelin and increased tryglyceride and leptin levels in the hindmilk might be associated with the important role of self-control when feeding BF infants. The stable content of formulas might be associated with a lack of self-control during feeding and increased nutrition. Changing the breast milk ghrelin, leptin, and fat levels between the foremilk and hindmilk and between the first and second visits might explain the differences in the weight gain patterns of BF and FF infants.en_US
dc.identifier.doi10.1007/s00431-011-1438-1en_US
dc.identifier.endpage1280en_US
dc.identifier.issn0340-6199en_US
dc.identifier.issn1432-1076en_US
dc.identifier.issue10en_US
dc.identifier.pmid21384109en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1273en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00431-011-1438-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26209
dc.identifier.volume170en_US
dc.identifier.wosWOS:000294960000007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofEUROPEAN JOURNAL OF PEDIATRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBreast milken_US
dc.subjectSelf-regulation of feedingen_US
dc.subjectGhrelinen_US
dc.subjectLeptinen_US
dc.subjectFaten_US
dc.subjectGrowthen_US
dc.titleBreastmilk ghrelin, leptin, and fat levels changing foremilk to hindmilk: is that important for self-control of feeding?en_US
dc.typeArticleen_US

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