Effects of endogenous molasses carbon dots on macrophages and their potential utilization as anti-inflammatory agents
Yükleniyor...
Dosyalar
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SPRINGER HEIDELBERG
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The biological effect of endogenous food-borne carbon dots (CDs) is one of the controversial issues of current research areas in food biotechnology. In this study, the biocompatibility and biofunctionality of sugar beet molasses-derived fluorescent carbon dots (CDs) were investigated for the first time in mammalian macrophage and fibroblast cells. The molasses CDs were nearly spherical in shape and monodispersed with a typical amorphous structure and a particle size distribution in the range of 1.3-3.8 nm. The anionic molasses CDs could easily enter the cells and exhibited excellent biocompatibility. Importantly, CDs with high photostability not only enabled the intracellular tracking of the nanomaterials by confocal microscopy, but also could reduce the LPS-induced NO production in RAW 264.7 cells. Altogether, endogenous CDs with dual functionality, bioimaging and anti-inflammatory effect, are believed to have great potential as macrophage-mediated theranostic agents.
Açıklama
Anahtar Kelimeler
endogenous molasses carbon, macrophages, anti-inflammatory agents
Kaynak
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
126
Sayı
1
Künye
Yavuz, E., Dinc, S., Kara, M. (2020). Effects of Endogenous Molasses Carbon Dots on Macrophages and Their Potential Utilization as Anti-Inflammatory Agents. Applied Physics A: Materials Science & Processing, 126(1), 22.
