Effects of endogenous molasses carbon dots on macrophages and their potential utilization as anti-inflammatory agents

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dc.contributor.authorYavuz, Emine.
dc.contributor.authorDinc, Saliha.
dc.contributor.authorKara, Meryem.
dc.date.accessioned2020-03-26T20:20:14Z
dc.date.available2020-03-26T20:20:14Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe biological effect of endogenous food-borne carbon dots (CDs) is one of the controversial issues of current research areas in food biotechnology. In this study, the biocompatibility and biofunctionality of sugar beet molasses-derived fluorescent carbon dots (CDs) were investigated for the first time in mammalian macrophage and fibroblast cells. The molasses CDs were nearly spherical in shape and monodispersed with a typical amorphous structure and a particle size distribution in the range of 1.3-3.8 nm. The anionic molasses CDs could easily enter the cells and exhibited excellent biocompatibility. Importantly, CDs with high photostability not only enabled the intracellular tracking of the nanomaterials by confocal microscopy, but also could reduce the LPS-induced NO production in RAW 264.7 cells. Altogether, endogenous CDs with dual functionality, bioimaging and anti-inflammatory effect, are believed to have great potential as macrophage-mediated theranostic agents.en_US
dc.identifier.citationYavuz, E., Dinc, S., Kara, M. (2020). Effects of Endogenous Molasses Carbon Dots on Macrophages and Their Potential Utilization as Anti-Inflammatory Agents. Applied Physics A: Materials Science & Processing, 126(1), 22.
dc.identifier.doi10.1007/s00339-019-3189-1en_US
dc.identifier.issn0947-8396en_US
dc.identifier.issn1432-0630en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00339-019-3189-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38539
dc.identifier.volume126en_US
dc.identifier.wosWOS:000502807900008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYavuz, Emine.
dc.institutionauthorDinc, Saliha.
dc.institutionauthorKara, Meryem.
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofAPPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSINGen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectendogenous molasses carbon
dc.subjectmacrophages
dc.subjectanti-inflammatory agents
dc.titleEffects of endogenous molasses carbon dots on macrophages and their potential utilization as anti-inflammatory agentsen_US
dc.typeArticleen_US

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