Investigation of Plant Sterols, Oxidized Low Density Lipoproteins (LDL) and Homocysteine Levels in Patients with Coronary Arthery Disease and Healthy Controls
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nobel Ilac
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışma serum bitki sterollerinin (B- sitosterol, stigmasterol) koroner arter hastalığının gelişi- mindeki rolünü ve diğer potansiyel risk faktörleriyle korelasyonunu göstermek için yapıldı.
Materyal ve Metod: Anjiografisi yapılan toplam 166 kişi koroner anjiografi sonuçlarına göre kontrol ve hasta olarak gruplandırıldı. Anjiografisi normal olan 60 kışı kontrol grubunu, üç majör koroner arterlerinin en az birinde > %50 stenozu olan 106 kişi hasta grubunu oluşturdu. Vakaların serum ß-sitosterol, stigmasterol, okside LDL ve homosistein düzeyleri analiz edildi
Bulgular: Hastalarım serum ß-sitosterol, stigmasterol ve bunların kolesterole oranları, okside LDL ve homosistein düzeyleri kontrollere göre biraz yüksek (istatistiksel açıdan önemsiz) bulundu. Üç hastanın serum bitki sterol seviyelen diğerlerine göre çok yüksekti. Hasta grubunda ẞ-sitosterol ile kolesterol düzeyleri arasında, kontrol grubunda stigmasterol ile kolesterol düzeyleri arasında önemli pozitif korelasyon vardı. Serum bitki sterolleri ile bunların okside LDL, homo- sistein ve koroner oklüzyon seviyeleri arasında ise korelasyon yoktu.
• Sonuç: Bulgularımız serum bitki sterollerinin koroner arter hastalarında bağımsız risk faktörü olmadığım göstermektedir. Aynca bu hastalarda diğer risk faktörlerinin yanında serum bitki sterollerinin de rutin olarak ölçülmesmin hastaların daha iyi değerlendirilmesinde çok önemli olacağı kanaatindeyiz.
Objective: This study was performed to demonstrate the role of serum plant sterols (?-sitosterol, stigmasterol in the development of coronary artery disease (CAD) and the correlation of them with other potential risk factors. Material and Method: Totally 166 subjects who underwent angiography were classified according to their coronary angiography results. Control group consisted of 60 subjects with normal coronary angiograms. Patient group consisted of 106 subjects with ? 50% stenosis in at least one of three major coronary arteries, Serum B-sitosterol, stigmasterol, oxidized low density lipoprotein (Ox-LDL) and homocysteine levels were measured. Results: Serum ß-sitosterol, stigmasterol, their ratios to cholesterol, Ox-LDL and homocysteine levels of patients were slightly but not significantly higher than those of controls Serum plant sterol levels of three patients were very high compared to those of the other subjects. There was a significant positive correlation between B-sitosterol and cholesterol in the patients group and between stigmasterol and cholesterol levels in the control group. However, there was no correlation between serum plant sterols levels and those of Ox-LDL homocysteine and the degree of coronary acclusion. Conclusion: Our results show that serum plant sterols are not independent risk factors for CAD. However, routine measurement of serum plant sterols in addition to other risk factors seems to be very important for a more reliable evaluation of patients with CAD.
Objective: This study was performed to demonstrate the role of serum plant sterols (?-sitosterol, stigmasterol in the development of coronary artery disease (CAD) and the correlation of them with other potential risk factors. Material and Method: Totally 166 subjects who underwent angiography were classified according to their coronary angiography results. Control group consisted of 60 subjects with normal coronary angiograms. Patient group consisted of 106 subjects with ? 50% stenosis in at least one of three major coronary arteries, Serum B-sitosterol, stigmasterol, oxidized low density lipoprotein (Ox-LDL) and homocysteine levels were measured. Results: Serum ß-sitosterol, stigmasterol, their ratios to cholesterol, Ox-LDL and homocysteine levels of patients were slightly but not significantly higher than those of controls Serum plant sterol levels of three patients were very high compared to those of the other subjects. There was a significant positive correlation between B-sitosterol and cholesterol in the patients group and between stigmasterol and cholesterol levels in the control group. However, there was no correlation between serum plant sterols levels and those of Ox-LDL homocysteine and the degree of coronary acclusion. Conclusion: Our results show that serum plant sterols are not independent risk factors for CAD. However, routine measurement of serum plant sterols in addition to other risk factors seems to be very important for a more reliable evaluation of patients with CAD.
Açıklama
International Symposium on New Trends on Clinical Biology Emerging Technologies/ SBCC/ BVKC -- MAY 15-17, 2008 -- Brussels, BELGIUM
Anahtar Kelimeler
Beta-sitosterol, Stigmasterol, Coronary artery disease, Oxidized low density lipoprotein, Homocysteine, Koroner arter hastalığı, Okside LDL, Homosistein
Kaynak
Nobel Medicus
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
6
Sayı
3
Künye
Sivrikaya, A., Mehmetoğlu, İ., Kurban, S., Aygül, N., Yerlikaya, F. H., (2010). Investigation of Plant Sterols, Oxidized Low Density Lipoproteins (LDL) and Homocysteine Levels in Patients with Coronary Arthery Disease and Healthy Controls. Nobel Medicus, 6(3), 39-45.
