Previous gestational diabetes history is associated with impaired coronary flow reserve

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dc.contributor.authorCaliskan, Mustafa
dc.contributor.authorTuran, Yasar
dc.contributor.authorCaliskan, Zuhal
dc.contributor.authorGullu, Hakan
dc.contributor.authorCiftci, Faika Ceylan
dc.contributor.authorAvci, Enver
dc.contributor.authorDuran, Cevdet
dc.date.accessioned2020-03-26T19:06:45Z
dc.date.available2020-03-26T19:06:45Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground Gestational diabetes mellitus (GDM) is a prediabetic state that is known to increase the risk of cardiovascular diseases. We have investigated coronary flow velocity reserve (CFVR) and epicardial fat thickness (EFT), and left ventricular diastolic function in patients with a history of previous GDM (p-GDM). Methods Ninety-three women with GDM history and 95 healthy women without GDM history were recruited. We used transthoracic Doppler echocardiography to assess CFVR, EFT, and left ventricular diastolic function. Insulin resistance of each subject was assessed with homeostasis model assessment insulin resistance (HOMA-IR). Hemoglobin A1c and high-sensitivity C-reactive protein (hsCRP) were also measured in all patients. Results CFVR values were significantly lower (2.34 +/- 0.39 versus 2.80 +/- 0.24, p<0.001) and EFT values were significantly higher in patients with p-GDM than the control group (5.5 +/- 1.3 versus 4.3 +/- 1.1, p<0.001). E/E' ratio (7.21 +/- 1.77 versus 6.53 +/- 1.38, p = 0.003), hemoglobin A1c (5.2 +/- 0.4 and 5.0 +/- 0.3, p = 0.001), HOMA-IR (2.8 +/- 1.4 versus 1.7 +/- 0.9, p = 0.04), and hsCRP levels were significantly higher in the p-GDM group than the control group. Multivariate analysis revealed that gestational diabetes history is independently associated with CFVR. Conclusion Women with a GDM history may be at more risk regarding coronary microvascular dysfunction compared to the healthy ones.en_US
dc.identifier.doi10.3109/07853890.2015.1099719en_US
dc.identifier.endpage623en_US
dc.identifier.issn0785-3890en_US
dc.identifier.issn1365-2060en_US
dc.identifier.issue7en_US
dc.identifier.pmid26555575en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage615en_US
dc.identifier.urihttps://dx.doi.org/10.3109/07853890.2015.1099719
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32462
dc.identifier.volume47en_US
dc.identifier.wosWOS:000365960700011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofANNALS OF MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCoronary flow reserveen_US
dc.subjectdiastolic functionen_US
dc.subjectepicardial fat thicknessen_US
dc.subjectgestational diabetesen_US
dc.subjectHbA1cen_US
dc.subjectHOMA-IRen_US
dc.titlePrevious gestational diabetes history is associated with impaired coronary flow reserveen_US
dc.typeArticleen_US

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