Inspection of Endothelial Nitric Oxide Synthase Gene Polymorphism in Patients With Henoch Schonlein Purpura

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dc.contributor.authorSomuncu, Makbule Nihan
dc.contributor.authorYildirim, Mahmut Selman
dc.contributor.authorZamani, Aysegul
dc.contributor.authorPeru, Harun
dc.date.accessioned2020-03-26T18:51:10Z
dc.date.available2020-03-26T18:51:10Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: This study aims to investigate the effect of Glu298Asp polymorphism, which is observed at endothelial nitric oxide synthase isoform particularly, having a significant impact on endothelial functions of nitric oxide synthase gene and on vascular system in patients with Henoch Schonlein purpura (HSP). Patients and methods: Ninety-five patients who were diagnosed with HSP and 93 healthy controls without any previous vascular disease, hypertension and other cardiovascular diseases were included in this study. The patient group was compared with the controls for Glu298Asp genotype and allele frequencies. The patients were classified according to the clinical complications and were compared with controls and also each other for allele and genotype frequencies. Real-time polymerase chain reaction and LightCycler (R) 2.0 system were used. Results: There was no statistically significant difference in the genotype frequencies between the HSP patients and healthy controls. No significant differences in Glu298Asp gene polymorphism among the patient groups were observed. However, polymorphism had an significant effect on patients with all involvements statistically (P-TT=0.001, P-GG=0.000). Conclusion: We conclude that Glu298Asp polymorphism has no effect on the development of HSP vasculitis; however, it may have an impact on the clinical progress of the existing disease.en_US
dc.description.sponsorshipUniversity of Necmettin Erbakan, Scientific Research Projects Department (BAP), Konya, Turkey [08202018]en_US
dc.description.sponsorshipThis research was supported by Grant 08202018 from University of Necmettin Erbakan, Scientific Research Projects Department (BAP), Konya, Turkey.en_US
dc.identifier.doi10.5606/ArchRheumatol.2014.3559en_US
dc.identifier.endpage80en_US
dc.identifier.issn2148-5046en_US
dc.identifier.issn1309-0283en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://dx.doi.org/10.5606/ArchRheumatol.2014.3559
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30935
dc.identifier.volume29en_US
dc.identifier.wosWOS:000339363300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTURKISH LEAGUE AGAINST RHEUMATISMen_US
dc.relation.ispartofARCHIVES OF RHEUMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEndothelial nitric oxide synthase geneen_US
dc.subjectGlu298Asp polymorphismen_US
dc.subjectHenoch Schonlein purpuraen_US
dc.subjectreal time polymerase chain reactionen_US
dc.titleInspection of Endothelial Nitric Oxide Synthase Gene Polymorphism in Patients With Henoch Schonlein Purpuraen_US
dc.typeArticleen_US

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