Evaluation of Antibiotic Susceptibilities and VISA-VRSA Rates Among MRSA Strains Isolated from Hospitalized Patients in Intensive Care Units of Hospitals in Seven Provinces of Turkey

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dc.contributor.authorCesur, Salih
dc.contributor.authorIrmak, Hasan
dc.contributor.authorSimsek, Husniye
dc.contributor.authorCoplu, Nilay
dc.contributor.authorKilic, Hasan
dc.contributor.authorArslan, Ugur
dc.contributor.authorBayramoglu, Gulcin
dc.date.accessioned2020-03-26T18:25:35Z
dc.date.available2020-03-26T18:25:35Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine whether vancomycin resistant Staphylococcus aureus (VRSA) and vancomycin intermediate susceptible S.aureus (VISA) strains were present among methicillin-resistant S.aureus (MRSA) strains isolated from patients hospitalised at intensive care units (ICU) of hospitals located at different regions of Turkey and to determine the minimum inhibitory concentration (MIC) values of teicoplanin, linezolid, tigecycline, quinupristin-dalfopristin and daptomycin, which are alternative drugs for the treatment of MRSA infections. A total of 260 MRSA clinical strains (isolated from 113 lower respiratory tract, 90 blood, 24 wound, 17 catheter, 13 nasal swabs, two urine and one CSF sample) were collected from nine health-care centers in eight provinces [Ankara (n=52), Konya (n=49), Antalya (n=40), Istanbul (n=7), Izmir (37), Diyarbakir (n=15), Van (n=12), Trabzon (n=48)] selected as representatives of the seven different geographical regions of Turkey. Methicillin resistance was determined by cefoxitin disk diffusion in the hospitals where the strains were isolated and confirmed by oxacillin salt agar screening at the Refik Saydam National Public Health Agency. Screening for VISA and VRSA was conducted using the agar screening test and E-test. Susceptibility of the MRSA strains to other antibiotics was also determined by E-test method. None of the 260 MRSA strains were determined to be VRSA or VISA. All were susceptible to teicoplanin and linezolid, and susceptibility rates to daptomycin, tigecycline and quinupristin-dalfopristin were 99.6%, 96.9%, and 95%, respectively. Absence of VISA and VRSA among the MRSA strains surveyed currently seemed hopeful, however, continuous surveillance is necessary. In order to prevent the development of VISA and VRSA strains the use of linezolid, tigecycline, quinupristin-dalfopristin and daptomycin should be encouraged as alternative agents of treatment of MRSA infections.en_US
dc.identifier.endpage358en_US
dc.identifier.issn0374-9096en_US
dc.identifier.issue3en_US
dc.identifier.pmid22951647en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage352en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28029
dc.identifier.volume46en_US
dc.identifier.wosWOS:000308115400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherANKARA MICROBIOLOGY SOCen_US
dc.relation.ispartofMIKROBIYOLOJI BULTENIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMethicillinen_US
dc.subjectresistanceen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectE-testen_US
dc.subjectantibiotic susceptibilityen_US
dc.subjectMRSAen_US
dc.subjectVISAen_US
dc.subjectTurkeyen_US
dc.titleEvaluation of Antibiotic Susceptibilities and VISA-VRSA Rates Among MRSA Strains Isolated from Hospitalized Patients in Intensive Care Units of Hospitals in Seven Provinces of Turkeyen_US
dc.typeArticleen_US

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