Antiproliferative constituents from the aerial parts of Chrysophthalmum montanum (DC.) Boiss
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Three undescribed sesquiterpene lactones (1-3), 1?,4?-dihydroxy-guaia-10(14),11(13)-dien-8?,12-olide (1), 4?, 6?-dihydroxy-9?,10?-epoxy-1?H-guaia-11(13)-en-8?,12-olide (2), and 4?,9?-dihydroxy-6?-acetoxy-1?H-guaia-10(14),11(13)-dien-8?,12-olide (3), as well as a known sesquiterpene lactone, (4?,5?,8?,10?)-4,10-dihydroxy-1,11(13)-guaiadien-12,8-olide (4), along with a lignan, pinoresinol (5), a flavonoid, chrysosplenol C (6), and two triterpenes, a mixture of isomers, taraxasterol acetate and ?-taraxasterol acetate (7a/7b), and a mixture of isomers taraxasterol and ?-taraxasterol (8a/8b) were isolated from the aerial parts of Chrysophthalmum montanum (DC.) Boiss. The structures of 1-6, 7a/7b, and 8a/8b were established on the basis of spectroscopic evidence, such as MS, NMR, UV, and IR spectroscopy. All isolated compounds, except for 5 and 8a/8b, were assayed for their antiproliferative activities against three human cancer cell lines, i.e. cervical (HeLa), breast (MCF-7), and lung (A549), and a normal human lung cell line (BEAS-2B) using MTT method. Compounds 1, 4, and 6 showed significant inhibitory effects on cancer cell growth at 20 ?g/mL concentration, with cell viability ranging from 53 to 64 % against MCF-7 cell line. In addition, compounds 4, and 6 exhibited cytotoxicity against HeLa cancer cell line with the viability of approximately 64 %. In conclusion, compounds 1, 4, and 6 may serve as leads for further research towards the development of anticancer agents. © 2020
Açıklama
Anahtar Kelimeler
Antiproliferative effect, Chrysophthalmum montanum, MTT assay, Sesquiterpene lactone
Kaynak
Phytochemistry Letters
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
36
