Antiproliferative constituents from the aerial parts of Chrysophthalmum montanum (DC.) Boiss

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dc.contributor.authorAyaz F.
dc.contributor.authorEmerce E.
dc.contributor.authorGören N.
dc.contributor.authorÇalış İ.
dc.contributor.authorUr Rehman M.
dc.contributor.authorIqbal Choudhary M.
dc.contributor.authorKüçükboyacı N.
dc.date.accessioned2020-03-26T20:20:42Z
dc.date.available2020-03-26T20:20:42Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThree undescribed sesquiterpene lactones (1-3), 1?,4?-dihydroxy-guaia-10(14),11(13)-dien-8?,12-olide (1), 4?, 6?-dihydroxy-9?,10?-epoxy-1?H-guaia-11(13)-en-8?,12-olide (2), and 4?,9?-dihydroxy-6?-acetoxy-1?H-guaia-10(14),11(13)-dien-8?,12-olide (3), as well as a known sesquiterpene lactone, (4?,5?,8?,10?)-4,10-dihydroxy-1,11(13)-guaiadien-12,8-olide (4), along with a lignan, pinoresinol (5), a flavonoid, chrysosplenol C (6), and two triterpenes, a mixture of isomers, taraxasterol acetate and ?-taraxasterol acetate (7a/7b), and a mixture of isomers taraxasterol and ?-taraxasterol (8a/8b) were isolated from the aerial parts of Chrysophthalmum montanum (DC.) Boiss. The structures of 1-6, 7a/7b, and 8a/8b were established on the basis of spectroscopic evidence, such as MS, NMR, UV, and IR spectroscopy. All isolated compounds, except for 5 and 8a/8b, were assayed for their antiproliferative activities against three human cancer cell lines, i.e. cervical (HeLa), breast (MCF-7), and lung (A549), and a normal human lung cell line (BEAS-2B) using MTT method. Compounds 1, 4, and 6 showed significant inhibitory effects on cancer cell growth at 20 ?g/mL concentration, with cell viability ranging from 53 to 64 % against MCF-7 cell line. In addition, compounds 4, and 6 exhibited cytotoxicity against HeLa cancer cell line with the viability of approximately 64 %. In conclusion, compounds 1, 4, and 6 may serve as leads for further research towards the development of anticancer agents. © 2020en_US
dc.description.sponsorship2214/A 02/2017-03 Türkiye Bilimsel ve Teknolojik Araştirma Kurumuen_US
dc.description.sponsorshipThis study was supported by Gazi University Research Foundation [grant number 02/2017-03 ], and the Scientific and Technological Research Council of Turkey (TUBITAK) 2211/A and 2214/A , from Turkey, as well as International Center for Chemical and Bological Sciences (ICCBS) – Hussain Ebrahim Jamal (HEJ) Research Institute of Chemistry from Pakistan.en_US
dc.identifier.doi10.1016/j.phytol.2020.01.003en_US
dc.identifier.endpage182en_US
dc.identifier.issn1874-3900en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.phytol.2020.01.003
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38648
dc.identifier.volume36en_US
dc.identifier.wosWOS:000535175100032en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofPhytochemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntiproliferative effecten_US
dc.subjectChrysophthalmum montanumen_US
dc.subjectMTT assayen_US
dc.subjectSesquiterpene lactoneen_US
dc.titleAntiproliferative constituents from the aerial parts of Chrysophthalmum montanum (DC.) Boissen_US
dc.typeArticleen_US

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