AN EVALUATION OF METABOLIC SYNDROME AND ITS COMPONENTS IN ALZHEIMER'S DISEASE: DOES GENDER MAKE A DIFFERENCE?

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dc.contributor.authorEge, Fahrettin
dc.contributor.authorOzturk, Serefnur
dc.contributor.authorYapar, Gulhan
dc.contributor.authorOzbakir, Scnay
dc.date.accessioned2020-03-26T18:13:44Z
dc.date.available2020-03-26T18:13:44Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction: Recent studies have indicated that vascular risk factors and metabolic syndrome may contribute to the process of Alzheimer's disease. The aim of this study was to evaluate the metabolic syndrome and its components in etiopathogenesis of Alzheimer's disease and the possible influences of these factors and gender. Materials and Method: Fifty-one patients were included in the study. Global deterioration scale and Standardized Mini-Mental Test (SMMT) were applied to all patients. Forty-two individuals with no cognitive complaint and normal results for SMMT were included as the control group. NCEP-ATP III criteria were used for the diagnosis of metabolic syndrome. Findings: Fifty-one patients (18 male, 33 female) and 42 controls (25 male, 17 female) were matched for age (73.47 +/- 6.49 and 73.04 +/- 4.61, respectively). The frequencies of metabolic syndrome (p=0.013) and its components [high waist circumference (p=0.001), hyperglycemia (p=0.05) and hypertriglyceridemia (p=0.040)] were significantly higher in female patients when compared to the male patients. Conclusion: Our results support a relation between Alzheimer's disease and metabolic syndrome and its components of high waist circumference, hyperglycemia and hypertriglyceridemia in women and suggest that different physiopathological mechanisms with respect to gender may be effective in this neurodegenerative process. Furthermore metabolic factors in women may contribute more prominently to the disease pathogenesis.en_US
dc.identifier.endpage376en_US
dc.identifier.issn1304-2947en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage369en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26113
dc.identifier.volume14en_US
dc.identifier.wosWOS:000298241300014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGUNES KITABEVI LTD STIen_US
dc.relation.ispartofTURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMetabolic Syndrome X/complicationsen_US
dc.subjectMetabolic Syndrome X/epidemiologyen_US
dc.subjectAlzheimer Diseaseen_US
dc.subjectDementiaen_US
dc.subjectRisk Factorsen_US
dc.titleAN EVALUATION OF METABOLIC SYNDROME AND ITS COMPONENTS IN ALZHEIMER'S DISEASE: DOES GENDER MAKE A DIFFERENCE?en_US
dc.typeArticleen_US

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