The End of Good Luck-Long-Term Survival Without Anticoagulation: A Case Report and Review of the Literature

Basit Öğe Kaydı
dc.contributor.authorGül, Enes Elvin
dc.contributor.authorAltunbaş, Gökhan
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorÖzdemir, Kurtuluş
dc.date.accessioned2020-03-26T18:31:44Z
dc.date.available2020-03-26T18:31:44Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractLong-term anticoagulation in patients with metallic prosthetic valve disease is required according to current guidelines. We describe a patient with a functioning mitral mechanical valve without anticoagulation for 27 years. A 46-year-old man admitted to the emergency department with complains of palpitation. The patient had a mitral valve replacement because of severe mitral stenosis. He discontinued warfarin treatment 1 month after surgery because of the unavailability of this drug in Turkey. Transthoracic echocardiography revealed functioning metalic mitral valve with a mean gradient of 9 mm Hg. Fluoroscopy showed normal excursions of the mechanical mitral valve. Transesophageal echocardiography was performed and revealed fresh thrombus formation in the left atrial appendix. Admission international normalized ration (INR) level was 1.79. Due to the higher INR level and long-term survival, genetic analysis of warfarin polymorphism was performed. There was a homozygous mutation in the vitamin K epoxide reductase complex 1 (VKORC1) 1173C>T and 1639G>A genotypes. The possible explanations of long-term survival and baseline higher INR level were linked to the mutation in warfarin metabolism. We also briefly review the literature.en_US
dc.identifier.doi10.1177/1076029611418966en_US
dc.identifier.endpage224en_US
dc.identifier.issn1076-0296en_US
dc.identifier.issue2en_US
dc.identifier.pmid21890569en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage222en_US
dc.identifier.urihttps://dx.doi.org/10.1177/1076029611418966
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28524
dc.identifier.volume18en_US
dc.identifier.wosWOS:000301287300018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.relation.ispartofCLINICAL AND APPLIED THROMBOSIS-HEMOSTASISen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectwarfarinen_US
dc.subjectprosthetic valveen_US
dc.subjectVKORC1en_US
dc.titleThe End of Good Luck-Long-Term Survival Without Anticoagulation: A Case Report and Review of the Literatureen_US
dc.typeReviewen_US

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