The use of adjunctive topical mitomycin in endoscopic congenital choanal atresia repair

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dc.contributor.authorBozkurt, M. K.
dc.contributor.authorKeles, B.
dc.contributor.authorAzimov, A.
dc.contributor.authorOzturk, K.
dc.contributor.authorArbag, H.
dc.date.accessioned2020-03-26T18:05:25Z
dc.date.available2020-03-26T18:05:25Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To evaluate the efficacy of topical mitomycin in providing the patency of the neochoanae in children undergoing transnasal endoscopic congenital choanal atresia (CA) repair. Methods: A retrospective analysis of surgical results in CA patients who were treated in Selcuk University, Meram Medical Faculty, Department of Otolaryngology between November 2002 and November 2009 was performed. All patients underwent transnasal endoscopic approach using nasal telescopes and traditional sinus instrumentation together with a microdebrider. Mitomycin was used according to the senior surgeon's preference, and certainly not in a randomized fashion. After completion of surgery, mitomycin 0.4 mg/ml was applied to the neochoanae for 3 min. Postoperative stenting was performed in all patients. Results: CA was unilateral in 8 subjects (mean age 71.8 +/- 41.7 months; range 18 months-144 months) and bilateral in 12 subjects (mean age 4.6 +/- 1.3 days; range 3-7 days). Among the subjects, 75% was female in both groups. Fourteen subjects under endoscopic repair without mitomycin, whereas mitomycin was used in 6 patients (4 bilateral, 2 unilateral). Stents were left at least 3 weeks postoperatively (mean 31 +/- 10 days; range 21-45 days). The patients were followed-up at least 6 months (range 6-72 months). No symptomatic restenosis requiring further dilatations was seen in patients treated with preoperative mitomycin, whereas restenosis was detected in 6 subjects (42.9%) treated without mitomycin postoperatively within 6 months period (Fisher's Exact Test 2-sided, p = 0.12). These subjects underwent revision endoscopic repair with mitomycin and had no need for further dilatations with acceptable control of symptoms during a follow-up period ranging between 14 and 78 months. Conclusion: Mitomycin improves the surgical treatment outcome of CA and reduces the rate of restenosis significantly without any complications. However, further prospective randomized studies are needed to fully investigate the benefits of mitomycin therapy in CA surgery. (C) 2010 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijporl.2010.03.026en_US
dc.identifier.endpage736en_US
dc.identifier.issn0165-5876en_US
dc.identifier.issue7en_US
dc.identifier.pmid20394996en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage733en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijporl.2010.03.026
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25418
dc.identifier.volume74en_US
dc.identifier.wosWOS:000279462400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER IRELAND LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChoanal atresiaen_US
dc.subjectMitomycin Cen_US
dc.subjectEndoscopicen_US
dc.titleThe use of adjunctive topical mitomycin in endoscopic congenital choanal atresia repairen_US
dc.typeArticleen_US

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