Multi-organ injuries caused by lipopolysaccharide-induced periodontal inflammation in rats: role of melatonin

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dc.contributor.authorGülle, K.
dc.contributor.authorAkpolat, Meryem
dc.contributor.authorKürçer, Z.
dc.contributor.authorCengiz, M. I.
dc.contributor.authorBaba, F.
dc.contributor.authorAçıkgöz, S.
dc.date.accessioned2020-03-26T18:51:40Z
dc.date.available2020-03-26T18:51:40Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and ObjectivePeriodontitis, a chronic inflammatory disease caused by oral bacterial infection, is considered to be a risk factor for systemic diseases including diabetes mellitus, bacterial pneumonia, hyperlipidemia and atherosclerosis. The aim of this study was to evaluate the effectiveness of melatonin against periodontal inflammation-induced multiple organ injury in rats. Material and MethodsEighteen female Wistar albino rats were randomly divided into three groups of six rats each: control; lipopolysaccharide (LPS); and LPS + melatonin. During the experimental period (10d) all rats in the LPS and LPS + melatonin groups were given 10L of LPS (from a 10mg/mL standard solution of LPS dissolved in saline) on days 1, 3 and 5. The rats in the LPS + melatonin group were given 50mg/kg of melatonin, daily for 10d, starting on day 1 after the administration of LPS. All rats were killed at the end of the experimental period. Liver, kidney and lung tissues were removed for investigation by light microscopy. ResultsThe levels of serum aspartate aminotransferase (AST), alanine transaminase (ALT) and blood urea nitrogen (BUN) were significantly increased in the LPS group compared with the LPS+ melatonin group (p<0.05). There was no significant change in the serum creatinine levels in the groups. However, the changes in serum AST, ALT and BUN levels in the experimental groups did not correlate with changes in histological data. Both LPS and LPS + melatonin groups displayed structural features similar to those of the control group. ConclusionThe results revealed that increased serum AST, ALT and BUN levels following periodontitis are ameliorated with melatonin treatment.en_US
dc.identifier.doi10.1111/jre.12156en_US
dc.identifier.endpage741en_US
dc.identifier.issn0022-3484en_US
dc.identifier.issn1600-0765en_US
dc.identifier.issue6en_US
dc.identifier.pmid24354339en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage736en_US
dc.identifier.urihttps://dx.doi.org/10.1111/jre.12156
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31010
dc.identifier.volume49en_US
dc.identifier.wosWOS:000345152300008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF PERIODONTAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthistopathologyen_US
dc.subjectmelatoninen_US
dc.subjectmultiorgan injuryen_US
dc.subjectperiodontitisen_US
dc.subjectraten_US
dc.titleMulti-organ injuries caused by lipopolysaccharide-induced periodontal inflammation in rats: role of melatoninen_US
dc.typeArticleen_US

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