Effects of hypothyroidism and hyperthyroidism on hematological parameters in rats

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dc.contributor.authorKandir, Sinan
dc.contributor.authorKeskin, Ercan
dc.date.accessioned2020-03-26T19:23:49Z
dc.date.available2020-03-26T19:23:49Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümüen_US
dc.description.abstractIn this study, it was aimed to interpret the effects of hypothyroidism and hyperthyroidism on hematological parameters in rats. A total of 42 male Wistar rats were divided into 3 equally groups as euthyroid, hypothyroid, hyperthyroid. Hypothyroidism and hyperthyroidism were induced by 6-n-propyl-2-thiouracil (PTU; 0,05%, w/v) and L-thyroxine (L-T4; 0,0012%, w/v) received in drinking water, respectively. Blood samples were withdrawn from 7 rats of each group at the end of 3rd and 6th weeks for determination of the hematological parameters and serum hormone profiles. Among the 3rd week groups only percentage of monocyte was increased (p<0.05) in the hypothyroid group when compared to the euthyroid group. In the 6th week hypothyroid group, red blood cell (RBC) counts, hemoglobin (Hb) concentration, hematocrit (Hct) value and percentage (%) of red cell distribution width (RDW) were lower (p<0.05) than the 6th week euthyroid and hyperthyroid groups. However, plateletcrit (PCT) % was higher (p<0.05) in the 6th week hypothyroid group compared to the 6th week euthyroid group. In the 6th week hyperthyroid group, mean corpuscular hemoglobin concentration (MCHC) and platelet (PLT) counts were lower (p<0.05) than the 6th week hypothyroid group. In the 6th week hyperthyroid group percentage of lymphocyte was decreased (p<0.05) and percentage of granulocyte was increased (p<0.05) when compared to the 6th week euthyroid group. In conclusion, elongation of the treatment duration with PTU and L-T4 could lead to changes on some hematological parameters. However, these values remained within physiological ranges.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects Coordination UnitSelcuk University [SUBAP-12102019]en_US
dc.description.sponsorshipThis study was partially supported by Selcuk University Scientific Research Projects Coordination Unit (Project No: SUBAP-12102019).en_US
dc.identifier.citationKandır, S., Keskin, E. (2016). Effects of Hypothyroidism and Hyperthyroidism on Hematological Parameters in Rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 63(4), 371-376.
dc.identifier.endpage376en_US
dc.identifier.issn1300-0861en_US
dc.identifier.issn1308-2817en_US
dc.identifier.issue4en_US
dc.identifier.startpage371en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33507
dc.identifier.volume63en_US
dc.identifier.wosWOS:000383889800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKandir, Sinan
dc.institutionauthorKeskin, Ercan
dc.language.isoenen_US
dc.publisherANKARA UNIV PRESSen_US
dc.relation.ispartofANKARA UNIVERSITESI VETERINER FAKULTESI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPropylthiouracilen_US
dc.subjectrat hematologyen_US
dc.subjectred blood cellsen_US
dc.subjectthyroid statusen_US
dc.titleEffects of hypothyroidism and hyperthyroidism on hematological parameters in ratsen_US
dc.typeArticleen_US

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