MMP-1, MMP-9, and TIMP-1 levels in oral lichen planus patients with gingivitis or periodontitis

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dc.contributor.authorErtugrul, Abdullah Seckin
dc.contributor.authorDursun, Recep
dc.contributor.authorDundar, Niyazi
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorHakki, Sema Sezgin
dc.date.accessioned2020-03-26T18:42:31Z
dc.date.available2020-03-26T18:42:31Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Oral lichen planus (OLP) is a chronic inflammatory disease of unknown aetiology. The aim of this study was to investigate matrix metalloproteinase (MMP)-1, MMP-9, and MMP inhibitor-1 (TIMP-1) levels in gingival crevicular fluid (GCF) by enzyme-linked immunosorbent assay and to investigate MMP-1, MMP-9, and TIMP-1 levels in gingival tissue by immunohistochemical staining of samples from patients with and without OLP. Design: Twenty-seven patients with OLP (gingivitis, OLPG; chronic periodontitis, OLPP) and thirty healthy non-OLP patients (gingivitis, HG; chronic periodontitis, HP) were included in this study. The MMP-1, MMP-9, and TIMP-1 levels in GCF were determined by enzyme-linked immunosorbent assay. The MMP-1, MMP-9, and TIMP-1 levels in gingival tissue were determined by immunohistochemical staining. Results: The mean levels of MMP-1 and MMP-9 in the GCF of OLPP patients were significantly higher and TIMP-1 was significantly lower than in HP patients; similarly, the mean levels of MMP-1 and MMP-9 were higher and TIMP-1 was significantly lower in OLPG patients than in HG patients. Our findings illustrate that tissue MMP-9 levels were statistically higher and TIMP-1 level were significantly lower in the OLPP group in comparison to the HP group, and the OLPG group in comparison to the HG group. The tissue MMP-1 level in the non-OLP group was found to be lower when compared with the OLP groups. But not statistically significant. Conclusions: Increased levels of MMP-1 and MMP-9 with decreased levels of TIMP-1 in GCF and increased MMP-1, MMP-9 levels and decreased TIMP-1 levels in the gingival tissue of OLP patients in combination with poor oral hygiene may cause increased tissue breakdown. The results of our study provide information about the effects of the periodontal status on the enzyme profiles in GCF and gingival tissue of OLP and non-OLP patients. (C) 2013 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipSelcuk University Research FoundationSelcuk University [BAP 06202034]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-HD-188/106S340]en_US
dc.description.sponsorshipThis study was supported by the Selcuk University Research Foundation (BAP 06202034) and TUBITAK (SBAG-HD-188/106S340).en_US
dc.identifier.doi10.1016/j.archoralbio.2013.01.015en_US
dc.identifier.endpage852en_US
dc.identifier.issn0003-9969en_US
dc.identifier.issn1879-1506en_US
dc.identifier.issue7en_US
dc.identifier.pmid23433942en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage843en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.archoralbio.2013.01.015
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29649
dc.identifier.volume58en_US
dc.identifier.wosWOS:000320417500012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofARCHIVES OF ORAL BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectOral lichen planusen_US
dc.subjectMMP-1en_US
dc.subjectMMP-9en_US
dc.subjectTIMP-1en_US
dc.subjectChronic periodontitisen_US
dc.subjectGingivitisen_US
dc.titleMMP-1, MMP-9, and TIMP-1 levels in oral lichen planus patients with gingivitis or periodontitisen_US
dc.typeArticleen_US

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