Efficacy of a low-dose spinal morphine with bupivacaine for postoperative analgesia in children undergoing hypospadias repair

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dc.contributor.authorApılıoğulları, Seza
dc.contributor.authorDuman, Ateş
dc.contributor.authorGök, Funda
dc.contributor.authorAkıllıoğlu, İshak
dc.contributor.authorÇiftçi, İlhan
dc.date.accessioned2020-03-26T17:38:31Z
dc.date.available2020-03-26T17:38:31Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractP>Background: Children undergoing hypospadias repair need to be protected from highly unpleasant sensory and emotional experiences during and after surgery. We designed a double-blinded, randomized, and placebo-controlled study to compare the efficacy of a low-dose (2 mu g center dot kg-1) of intrathecal morphine with placebo for postoperative pain control of children undergoing repair of hypospadias surgery with spinal anesthesia. Methods: Fifty-four children were randomly assigned to one of two spinal anesthesia groups. Group M (n = 27) received hyperbaric bupivacaine plus 2 mu g center dot kg-1 of preservative-free morphine and group P (n = 27) received hyperbaric bupivacaine plus 0.9% NaCl (placebo) under inhalation anesthesia. General anesthetics were discontinued subsequent to the block. The primary outcome was the presence of pain-requiring analgesics during the first 12 h after the spinal block. Side effects were also recorded. The analgesic effects were evaluated by using the Children's Hospital of Eastern Ontario Pain Scale. Results: Forty-nine patients completed the trial. Fifteen patients (60%) in group P received supplementary analgesics within the first 12 h compared to only four patients (16.7%) in group M (P = 0.005). Mean duration of analgesia was 480 +/- 209 and 720 +/- 190 min in group P and group M respectively (P = 0.009). The groups were similar in postoperative side effects. Conclusion: Spinal anesthesia provided by hyperbaric bupivacaine is adequate for distal hypospadias repair in children, but adding 2 mu g center dot kg-1 intrathecal morphine provides better postoperative pain control when compared to placebo in these children.en_US
dc.identifier.doi10.1111/j.1460-9592.2009.03136.xen_US
dc.identifier.endpage1083en_US
dc.identifier.issn1155-5645en_US
dc.identifier.issue11en_US
dc.identifier.pmid19708911en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1078en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1460-9592.2009.03136.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23501
dc.identifier.volume19en_US
dc.identifier.wosWOS:000270551800007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELL PUBLISHING, INCen_US
dc.relation.ispartofPEDIATRIC ANESTHESIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbupivacaineen_US
dc.subjectchildrenen_US
dc.subjecthypospadiasen_US
dc.subjectintrathecal morphineen_US
dc.subjectpostoperative painen_US
dc.titleEfficacy of a low-dose spinal morphine with bupivacaine for postoperative analgesia in children undergoing hypospadias repairen_US
dc.typeArticleen_US

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