Influence of different extraction techniques on the chemical profile and biological properties of Anthemis cotula L.: Multifunctional aspects for potential pharmaceutical applications

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dc.contributor.authorSut, Stefania
dc.contributor.authorDall'Acqua, Stefano
dc.contributor.authorZengin, Gökhan
dc.contributor.authorŞenkardeş, İsmail
dc.contributor.authorBulut, Gizem
dc.contributor.authorCvetanovic, Aleksandra
dc.contributor.authorStupar, Alena
dc.contributor.authorMandić, Anamarija
dc.contributor.authorPicot-Allain, Carene
dc.contributor.authorDoğan, Ahmet
dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorMahomoodally, Fawzi
dc.date.accessioned2020-03-26T20:14:44Z
dc.date.available2020-03-26T20:14:44Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe phytochemical composition of different extracts obtained from stinking chamomile (Anthemis cotula L) was investigated. Ethanol was used as solvent and accelerated solvent extraction (ASE), microwave assisted extraction (MAE), maceration, soxhlet extraction (SE), and ultrasound assisted extraction (UAE) were applied on plant material. Comparison of the phytochemical contents, antioxidant, and enzyme inhibitory properties were performed. The most abundant sesquiterpene in the extracts was anthecotuloide, while the most present phenolics were caffeoyl quinic acid, quercetin, and kaempferol derivatives. UAE extract was the most efficient in the extraction of sesquiterpenoids and polyphenols. Considering the assays on antioxidant activity and enzyme inhibition, ASE extract showed highest phenolic content (62.92 mg gallic acid equivalent/g extract). Likewise, this extract showed highest radical scavenging (103.44 mg trolox equivalent [TE]/g extract and 155.70 mg TE/g extract, for DPPH and ABTS assays respectively) and reducing power potential (435.32 and 317.89 mg TE/g extract, for CUPRAC and FRAP assays, respectively). The different extracts showed similar results in the enzyme inhibition assays suggesting that the extraction methods used have no effect on observed enzyme activities. Novelty of our findings are the inhibitory action of the ethanol extract of A. cotula aerial parts on key enzymes associated with Alzheimer's disease (acetyl cholinesterase, butyryl cholinesterase), type 2 diabetes (alpha-amylase, alpha-glucosidase), and skin hyperpigmentation disorders (tyrosinase). Data collected from the present work further appraises the multiple potential biological properties of stinking chamomile suggesting the need for further investigation on its constituents. (C) 2019 Elsevier B.V. All rights reserved.en_US
dc.identifier.citationSut, S., Dall’Acqua, S., Zengin, G., Senkardes, I., Bulut, G., Cvetanović, A., Stupar, A., Mandić, A., Picot-Allain, C., Dogan, A., Sinan, K. I., Mahomoodally, F. (2019). Influence Of Different Extraction Techniques On The Chemical Profile And Biological Properties Of Anthemis Cotula L.: Multifunctional Aspects For Potential Pharmaceutical Applications. Journal Of Pharmaceutical And Biomedical Analysis, 173, 75-85.
dc.identifier.doi10.1016/j.jpba.2019.05.028en_US
dc.identifier.endpage85en_US
dc.identifier.issn0731-7085en_US
dc.identifier.issn1873-264Xen_US
dc.identifier.pmid31121457en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpba.2019.05.028
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37928
dc.identifier.volume173en_US
dc.identifier.wosWOS:000472238700010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnthemis cotulaen_US
dc.subjectH-1-NMRen_US
dc.subjectAnthecotuloideen_US
dc.subjectSesquiterpenoidsen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitoren_US
dc.titleInfluence of different extraction techniques on the chemical profile and biological properties of Anthemis cotula L.: Multifunctional aspects for potential pharmaceutical applicationsen_US
dc.typeArticleen_US

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