Migraine and subclinical atherosclerosis: endothelial dysfunction biomarkers and carotid intima-media thickness: a case-control study

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dc.contributor.authorAvcı, Aynur Yılmaz
dc.contributor.authorAkküçük, Mehmet Hüsamettin
dc.contributor.authorTorun, Ebru
dc.contributor.authorArıkan, Serap
dc.contributor.authorCan, Ufuk
dc.contributor.authorTekindal, Mustafa Agah
dc.date.accessioned2020-03-26T20:15:13Z
dc.date.available2020-03-26T20:15:13Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümüen_US
dc.description.abstractBackground Migraine is a common neurovascular disease associated with vascular risks, especially in young adult females, but the mechanism underlying these associations remains unknown. This study evaluated the relationships between plasma endothelial dysfunction biomarkers and carotid intima-media thickness (IMT) in young adult females with migraine. Methods This case-control study included 148 female patients (age range: 18-50years). Migraine was diagnosed according to the International Headache Society-IIIb criteria. Endothelial dysfunction biomarkers, such as von Willebrand factor (vWF), C-reactive protein (CRP), homocysteine, total nitrate/nitrite concentration, and thiobarbituric acid-reactive substances (TBARS), were evaluated in plasma. Carotid IMT was measured by a radiologist with sonography. Results The CRP, TBARS, vWF, and IMT levels were increased in the migraine compared with the control group (p<0.001, p=0.02, p<0.001, and p<0.001, respectively). After adjusting for confounders, multiple linear regression analysis revealed that systolic arterial blood pressure, CRP, vWF, TBARS, and right and left internal carotid artery (ICA) IMT were independently positively correlated with migraine (p<0.01, p=0.004, p=0.023, p=0.024, p=0.032, and p=0.048, respectively). Multiple logistic regression analysis revealed that right ICA IMT was independently associated with ergotamine and triptan and left ICA IMT was independently associated with ergotamine (p=0.013, p=0.026, and p=0.017, respectively). In addition, significant correlations were found between LDL lipoprotein and carotid IMT in the migraine group (p<0.05). Conclusions Carotid IMT enhancement and elevated TBARS, vWF, and CRP levels in migraine subjects during a migraine attack could be regarded as consequences of migraine attack pathophysiology. The independent associations between triptan and ergotamine consumption and enhanced carotid IMT suggest that repeated use of these vasoconstrictive antimigraine agents may have additional effects on carotid IMT.en_US
dc.description.sponsorshipBaskent University Research FundBaskent Universityen_US
dc.description.sponsorshipThis study was supported by the Baskent University Research Fund.en_US
dc.identifier.citationAvci, A. Y., Akkucuk, M. H., Torun, E., Arikan, S., Can, U., Tekindal, M. A. (2019). Migraine And Subclinical Atherosclerosis: Endothelial Dysfunction Biomarkers And Carotid İntima-Media Thickness: A Case-Control Study. Neurological Sciences, 40,(4), 703-711.
dc.identifier.doi10.1007/s10072-019-3710-5en_US
dc.identifier.endpage711en_US
dc.identifier.issn1590-1874en_US
dc.identifier.issn1590-3478en_US
dc.identifier.issue4en_US
dc.identifier.pmid30645751en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage703en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10072-019-3710-5
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38000
dc.identifier.volume40en_US
dc.identifier.wosWOS:000464766700005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTekindal, Mustafa Agah
dc.language.isoenen_US
dc.publisherSPRINGER-VERLAG ITALIA SRLen_US
dc.relation.ispartofNEUROLOGICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCoagulationen_US
dc.subjectC-reactive proteinen_US
dc.subjectHeadacheen_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.subjectVascular risken_US
dc.titleMigraine and subclinical atherosclerosis: endothelial dysfunction biomarkers and carotid intima-media thickness: a case-control studyen_US
dc.typeArticleen_US

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