Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats

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dc.contributor.authorEr, Ayse
dc.date.accessioned2020-03-26T18:41:11Z
dc.date.available2020-03-26T18:41:11Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromycin group, where azithromycin was administered orally at 350 mg kg(-1) day on days 9, 10, and 11 of pregnancy; lipopolysaccharide group, where LPS was administered intravenously via the tail vein at 160 mu g kg(-1) on day 10 of pregnancy; and the azithromycin + LPS group, where azithromycin was administered orally at 350 mg kg(-1) day on days 9, 10, and 11 of pregnancy and LPS was administered intravenously at 160 mu g kg(-1) on day 10 of pregnancy. Blood samples were obtained from the tail vein on day 10 of the experiment. Pregnancy rates were determined. Tumor necrosis factor-alpha (TNF-alpha) and interleukin( IL-10) levels were measured by ELISA. Azithromycin prevented (P < 0.05) LPS-induced pregnancy loss. Higher TNF-alpha and IL-10 levels were measured (P < 0.05) in the LPS and azithromycin + LPS groups, respectively. In conclusion, azithromycin may be useful in infection- or endotoxemia-dependent pregnancy loss.en_US
dc.identifier.doi10.1155/2013/928137en_US
dc.identifier.issn0962-9351en_US
dc.identifier.issn1466-1861en_US
dc.identifier.pmid24371377en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1155/2013/928137
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29258
dc.identifier.wosWOS:000327978100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHINDAWI PUBLISHING CORPORATIONen_US
dc.relation.ispartofMEDIATORS OF INFLAMMATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleAzithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Ratsen_US
dc.typeArticleen_US

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