Heat Shock Proteins; An Overview
Yükleniyor...
Dosyalar
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
BENTHAM SCIENCE PUBL LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Heat shock proteins (Hsps) protect protein substrates against conformational damage to promote the function of the proteins, prevent aggregation and prevent formation of toxic inclusion bodies. Protein aggregates and fibrils have been associated with neurodegenerative diseases and with inclusion bodies. High-level expression of recombinant protein for biotechnological purposes often leads to insoluble inclusion bodies. Therefore, misfolded proteins must be properly folded or must be degraded through heat shock protein action. This function protects cells against cytotoxic outcomes. In addition to their cytoprotective roles, Hsps are involved in other functions since Hsps exist in all types of cells and tissues. Therefore, several diseases are associated with alterations of these biochemical functions. This first review of the theme issue will discuss general properties of Hsps concisely along with their potential use in pharmaceutical and biotechnological applications.
Açıklama
Anahtar Kelimeler
Heat Shock Protein, Biotechnology, Pharmacology
Kaynak
Current Pharmaceutical Biotechnology
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
11
Sayı
2
Künye
Tutar, L., Tutar, Y., (2010). Heat Shock Proteins; An Overview. Current Pharmaceutical Biotechnology, 11(2), 216-222.
DOI: 10.2174/138920110790909632
