Novel copper(II) complexes of p-tert-butylcalix[4]arene diamide derivatives: synthesis, antimicrobial and DNA cleavage activities
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TAYLOR & FRANCIS LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, two new Cu(II) complexes of p-tert-butylcalix[4]arene amide derivatives (8, 9) have been synthesised and investigated their DNA cleavage and antimicrobial activities. On the basis of spectral studies, a smaller distortion of square planar geometry has been proposed for both of the copper(II) complexes. The DNA cleavage studies show that the ligands are not efficacious, whereas the complexes have high activity. Futhermore, in order to determine the site of DNA cleavage, the DNA interactions of these compounds were investigated with some restriction enzymes. In addition, all synthesised compounds were screened for antimicrobial activities against some bacteria and for antifungal activities against yeast strains. The results showed that ethyl ester and furfuryl amide derivatives of the calixarenes are more efficient than other compounds against tested bacteria. However, complexes have not been effective. In case of DNA interaction studies, compounds were very effective against plasmid DNA.
Açıklama
Anahtar Kelimeler
restriction enzyme, copper(II) complex, EPR, DNA cleavage activity, calix[4]arene, antimicrobial
Kaynak
SUPRAMOLECULAR CHEMISTRY
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
27
Sayı
4
