Novel copper(II) complexes of p-tert-butylcalix[4]arene diamide derivatives: synthesis, antimicrobial and DNA cleavage activities

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dc.contributor.authorÖzkan, Şeyda Çiğdem
dc.contributor.authorYılmaz, Aydan
dc.contributor.authorArslan, Emine
dc.contributor.authorAçık, Leyla
dc.contributor.authorSayın, Ülkü
dc.contributor.authorMutlu, Elif Gülbahçe
dc.date.accessioned2020-03-26T19:06:28Z
dc.date.available2020-03-26T19:06:28Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, two new Cu(II) complexes of p-tert-butylcalix[4]arene amide derivatives (8, 9) have been synthesised and investigated their DNA cleavage and antimicrobial activities. On the basis of spectral studies, a smaller distortion of square planar geometry has been proposed for both of the copper(II) complexes. The DNA cleavage studies show that the ligands are not efficacious, whereas the complexes have high activity. Futhermore, in order to determine the site of DNA cleavage, the DNA interactions of these compounds were investigated with some restriction enzymes. In addition, all synthesised compounds were screened for antimicrobial activities against some bacteria and for antifungal activities against yeast strains. The results showed that ethyl ester and furfuryl amide derivatives of the calixarenes are more efficient than other compounds against tested bacteria. However, complexes have not been effective. In case of DNA interaction studies, compounds were very effective against plasmid DNA.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University, Konya-TurkeySelcuk University [BAP 2009/10201020]en_US
dc.description.sponsorshipWe thank the Research Foundation of Selcuk University, Konya-Turkey [grant number BAP 2009/10201020] for its financial support of this work produced from a part of S.C. Ozkan's MS thesis.en_US
dc.identifier.doi10.1080/10610278.2014.978868en_US
dc.identifier.endpage267en_US
dc.identifier.issn1061-0278en_US
dc.identifier.issn1029-0478en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage255en_US
dc.identifier.urihttps://dx.doi.org/10.1080/10610278.2014.978868
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32369
dc.identifier.volume27en_US
dc.identifier.wosWOS:000347685700005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofSUPRAMOLECULAR CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectrestriction enzymeen_US
dc.subjectcopper(II) complexen_US
dc.subjectEPRen_US
dc.subjectDNA cleavage activityen_US
dc.subjectcalix[4]areneen_US
dc.subjectantimicrobialen_US
dc.titleNovel copper(II) complexes of p-tert-butylcalix[4]arene diamide derivatives: synthesis, antimicrobial and DNA cleavage activitiesen_US
dc.typeArticleen_US

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