Scrophularia Lucida L. As A Valuable Source Of Bioactive Compounds For Pharmaceutical Applications: In Vitro Antioxidant, Anti-İnflammatory, Enzyme İnhibitory Properties, İn Silico Studies, And HPLC Profiles

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorStefanucci, Azzurra
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorMollica, Adriano
dc.contributor.authorCustodio, Luisa
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T20:19:15Z
dc.date.available2020-03-26T20:19:15Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe genus Scrophularia has received much interest with regards to its traditional uses against eczema, psoriasis, and mastitis. Yet, the medicinal properties of some species still need to be scientifically validated. The present study was designed to investigate into the biological properties of various solvent extracts (ethyl acetate, methanol, and aqueous) of the roots and aerial parts of Scrophularia lucida based on its antioxidant, anti-inflammatory, and enzyme inhibitory activities together with phytochemical screening. Our results revealed that the solvent extracts differed in their biological effectiveness. The root ethyl acetate extract showed the highest ABTS scavenging, FRAP, CUPRAC, and inhibitory activity against AChE and alpha-glucosidase. The ethyl acetate extract of the aerial parts displayed the highest BChE and alpha-amylase inhibition and antioxidant effect in the phosphomolybdenum assay, while the methanol extracts of both parts were the most effective DPPH center dot scavengers and tyrosinase inhibitors. The methanol extracts of the root and aerial parts also inhibited NO production in lipopolysaccharide (LPS)-stimulated murine leukemic monocyte-macrophage cell (4.99% and 10.77%, respectively), at 31.25 mu g/mL concentration. The highest TPC (34.98 mg GAE/g extract) and TFC (48.33 mg RE/g extract) were observed in the ethyl acetate extract of the root and aerial parts, respectively. The most abundant compounds in the root ethyl acetate extract were luteolin (852 mu g/g extract), rosmarinic acid (522 mu g/g extract), and hesperidin (394 mu g/g extract) while kaempferol was most abundant in the ethyl acetate extract of the aerial parts (628 mu g/g extract). In silico experiments were conducted on tyrosinase and the higher docking values were observed for rosmarinic acid and hesperidin. The present findings provide base line information which tend to support the potential use of S. lucida in the management of several chronic diseases, including Alzheimer's disease and diabetes mellitus. (C) 2018 Elsevier B.V. All rights reserved.en_US
dc.identifier.citationZengin, G., Stefanucci, A., Rodrigues, M. J., Mollica, A., Custodio, L., Aumeeruddy, M. Z., Mahomoodally, M. F. (2019). Scrophularia Lucida L. As A Valuable Source Of Bioactive Compounds For Pharmaceutical Applications: In Vitro Antioxidant, Anti-İnflammatory, Enzyme İnhibitory Properties, İn Silico Studies, And HPLC Profiles. Journal Of Pharmaceutical And Biomedical Analysis, 162, 225-233.
dc.identifier.doi10.1016/j.jpba.2018.09.035en_US
dc.identifier.endpage233en_US
dc.identifier.issn0731-7085en_US
dc.identifier.issn1873-264Xen_US
dc.identifier.pmid30268023en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage225en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpba.2018.09.035
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38179
dc.identifier.volume162en_US
dc.identifier.wosWOS:000449244100027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectS. lucidaen_US
dc.subjectAntioxidanten_US
dc.subjectTyrosinaseen_US
dc.subjectPhenolicen_US
dc.subjectDockingen_US
dc.subjectAnti-inflammatoryen_US
dc.titleScrophularia Lucida L. As A Valuable Source Of Bioactive Compounds For Pharmaceutical Applications: In Vitro Antioxidant, Anti-İnflammatory, Enzyme İnhibitory Properties, İn Silico Studies, And HPLC Profilesen_US
dc.typeArticleen_US

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