Coenzyme Q10 supplementation and regular physical exercise affect the level of glutathione and superoxide dismutase in the brain

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dc.contributor.authorRevan, Serkan
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorBalcı, Şükrü Serdar
dc.contributor.authorBelviranlı, Muaz
dc.contributor.authorPepe, Hamdi
dc.contributor.authorGökbel, Hakkı
dc.date.accessioned2020-03-26T18:44:36Z
dc.date.available2020-03-26T18:44:36Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The aim of the study was to evaluate the effects of coenzyme Q10 supplementation (CoQ10) and regular exercise on exhaustive-exercise induced oxidative stress and antioxidant response in rat brain. Materials and Methods: The experiments were carried out with young adult male Wistar rats. The rats were randomly assigned to one of the following eight groups: Untrained, trained, untrained exhausted, trained exhausted, untrained+CoQ10, trained+CoQ10, untrained exhausted+CoQ10 and trained exhausted+CoQ10. The rats in the trained groups swam for 60 min/day, five days per week for six weeks. The CoQ10 supplements were administered at a daily dose of 10 mg.kg-1 of body weight five days/week. Results: The levels of malondialdehyde and 8-hydroxydeoxyguanosine in the brain were not affected by exhaustive exercise, training and CoQ10 supplementation. The exhaustive exercise decreased GSH levels in the control group, while it increased in untrained and trained exhausted+CoQ10 groups. Swimming training increased SOD activity in the brain, but exhaustive exercise did not change its activity. CoQ10 supplementation increased SOD activity in control group, while it decreased in the trained group. Conclusion: The results suggested that exhaustive exercise does not cause lipid peroxidation and DNA damage in the brain. It can be said that regular exercise alone may be adequate for the positive effects on antioxidant enzymes in brain. © 2013 by Erciyes University School of Medicine.en_US
dc.identifier.citationRevan S., Okudan N., Balcı Ş. S., Belviranlı M., Pepe H., Gökbel H. (2013). Coenzyme Q10 supplementation and regular physical exercise affect the level of glutathione and superoxide dismutase in the brain. Erciyes Tip Dergisi, 35(3), 142-147.
dc.identifier.doi10.5152/etd.2013.43en_US
dc.identifier.endpage147en_US
dc.identifier.issn1300199Xen_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage142en_US
dc.identifier.urihttps://dx.doi.org/10.5152/etd.2013.43
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30021
dc.identifier.volume35en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofErciyes Tip Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidantsen_US
dc.subjectBrainen_US
dc.subjectCoenzyme Q10en_US
dc.subjectExerciseen_US
dc.subjectOxidative stressen_US
dc.titleCoenzyme Q10 supplementation and regular physical exercise affect the level of glutathione and superoxide dismutase in the brainen_US
dc.title.alternativeDüzenli egzersiz ve koenzim Q10 takviyesi beyin dokusunda GSH ve SOD düzeyini etkileren_US
dc.typeArticleen_US

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