Qualitative Chemical Characterization and Multidirectional Biological Investigation of Leaves and Bark Extracts of Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae)

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dc.contributor.authorOrlando, Giustino
dc.contributor.authorFerrante, Claudio
dc.contributor.authorZengin, Gökhan
dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorBene, Kouadio
dc.contributor.authorDiuzheva, Alina
dc.contributor.authorJeko, Jozsef
dc.contributor.authorCziáky, Zoltán
dc.contributor.authorDi Simone, Simonetta
dc.contributor.authorRecinella, Lucia
dc.contributor.authorChiavaroli, Annalisa
dc.contributor.authorLeone, Sheila
dc.contributor.authorBrunetti, Luigi
dc.contributor.authorPicot-Allain, Carene Marie Nancy
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorMenghini, Luigi
dc.date.accessioned2020-03-26T20:19:11Z
dc.date.available2020-03-26T20:19:11Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractAnogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) has a long history of use by folk populations for the management of multiple human ailments. Based on the published literature, there has been no attempt to conduct a comparative assessment of the biological activity and the phytochemical profiles of the leaves and stem bark of A. leiocarpus extracted using methanol, ethyl acetate, and water. By high-performance liquid chromatography with electrospray ionization mass spectrometric detection (HPLC-ESI-MSn) analysis, quinic, shikimic, gallic, and protocatechuic acids were tentatively identified from all the extracts, while chlorogenic, caffeic, ferulic, and dodecanedioic acids were only characterised from the leaves extracts. Additionally, a pharmacological study was carried out to evaluate potential protective effects that are induced by the extracts in rat colon and colon cancer HCT116 cell line. In general, the methanol and water extracts of A. leiocarpus leaves and stem bark showed potent radical scavenging and reducing properties. It was noted that the stem bark extracts were more potent antioxidants as compared to the leaves extracts. The methanol extract of A. leiocarpus leaves showed the highest acetyl (4.68 mg galantamine equivalent/g) and butyryl (4.0 mg galantamine equivalent/g) cholinesterase inhibition. Among ethyl acetate extracts, the pharmacological investigation suggested stem bark ethyl acetate extracts to be the most promising. This extract revealed ability to protect rat colon from lipopolysaccharide-induced oxidative stress, without exerting promoting effects on HCT116 cell line viability and migration. As a conclusion, A. leiocarpus represents a potential source of bioactive compounds in the development of novel therapeutic agents.en_US
dc.description.sponsorshipItalian Ministry of UniversityMinistero dell' Istruzione, dell' Universita e della Ricerca (MIUR)en_US
dc.description.sponsorshipThis work was supported by grants from the Italian Ministry of University (FAR 2016 granted to Claudio Ferrante; FAR 2018 granted to Giustino Orlando; FAR 2016 granted to Luigi Menghini).en_US
dc.identifier.citationOrlando, G., Ferrante, C., Zengin, G., Sinan, K. I., Bene, K., Diuzheva, A., Jeko, J., Cziáky, Z., Di Simone, S., Recinella, L., Chiavaroli, A., Leone, S., Brunetti, L., Picot-Allain, C. M. N., Mahomoodally, M. F., Menghini, L. (2019). Qualitative Chemical Characterization And Multidirectional Biological Investigation Of Leaves And Bark Extracts Of Anogeissus Leiocarpus (DC.) Guill. & Perr.(Combretaceae). Antioxidants, 8(9), 343.
dc.identifier.doi10.3390/antiox8090343en_US
dc.identifier.issn2076-3921en_US
dc.identifier.issue9en_US
dc.identifier.pmid31480498en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.3390/antiox8090343
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38140
dc.identifier.volume8en_US
dc.identifier.wosWOS:000487957300060en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofANTIOXIDANTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnogeissusen_US
dc.subjectbioactive compoundsen_US
dc.subjectantioxidanten_US
dc.subjectenzyme inhibitionen_US
dc.subjectulcerative colitisen_US
dc.titleQualitative Chemical Characterization and Multidirectional Biological Investigation of Leaves and Bark Extracts of Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae)en_US
dc.typeArticleen_US

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