The Effect of Supplementation of Grape Seed Proanthocyanidin Extract on Vascular Dysfunction in Experimental Diabetes

Basit Öğe Kaydı
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorBariskaner, Hulagu
dc.contributor.authorGokbel, Hakki
dc.contributor.authorSahin, Ayse Saide
dc.contributor.authorBelviranli, Muaz
dc.contributor.authorBaysal, Hatice
dc.date.accessioned2020-03-26T18:16:43Z
dc.date.available2020-03-26T18:16:43Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIncreased oxidative stress and impaired endothelium-dependent relaxation could underlie many of the vascular complications associated with diabetes. We aimed to investigate the effect of supplementation with grape seed proanthocyanidin extract (GSPE), a natural antioxidant, on vascular responses and oxidative stress in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into three groups: control rats, untreated diabetic rats, and GSPE (100 mg/kg, for 6 weeks)-supplemented diabetic rats. Thoracic aorta rings of the rats were mounted in organ baths, and relaxant responses to acetylcholine (ACh), A23187, and sodium nitroprusside (SNP) were assayed in tissues precontracted with 60mM KCl. Plasma samples used for the measurement of malondialdehyde (MDA) level and superoxide dismutase (SOD) activity. The endothelium-dependent relaxations in response to ACh and A23187 were impaired, but endothelium-independent relaxation in response to SNP did not change in diabetic rats. Supplementation with GSPE significantly improved the relaxant responses to ACh and A23187. The MDA level was significantly elevated and the plasma SOD activity was decreased in diabetic rats, but supplementation with GSPE attenuated the elevated MDA levels and increased plasma SOD activity. Thus supplementation of GSPE may attenuate oxidative stress through the inhibition of lipid peroxidation and may restore endothelial function and reduce the risk of vascular disease in diabetes.en_US
dc.identifier.doi10.1089/jmf.2010.0030en_US
dc.identifier.endpage1302en_US
dc.identifier.issn1096-620Xen_US
dc.identifier.issn1557-7600en_US
dc.identifier.issue11en_US
dc.identifier.pmid21663473en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1298en_US
dc.identifier.urihttps://dx.doi.org/10.1089/jmf.2010.0030
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26917
dc.identifier.volume14en_US
dc.identifier.wosWOS:000296748800002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMARY ANN LIEBERT, INCen_US
dc.relation.ispartofJOURNAL OF MEDICINAL FOODen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdiabetesen_US
dc.subjectgrape seed proanthocyanidinsen_US
dc.subjectvascular endotheliumen_US
dc.titleThe Effect of Supplementation of Grape Seed Proanthocyanidin Extract on Vascular Dysfunction in Experimental Diabetesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu