The evaluation of reliability and contribution of frozen section pathology to staging endometrioid adenocarcinomas

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dc.contributor.authorKarabagli, Pinar
dc.contributor.authorUgras, Serdar
dc.contributor.authorYilmaz, Burcu Sanal
dc.contributor.authorCelik, Cetin
dc.date.accessioned2020-03-26T19:07:31Z
dc.date.available2020-03-26T19:07:31Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTo evaluate the reliability and accuracy of intraoperative pathological findings, compared to permanent section (PS) and to understand contributions of frozen section (FS) to final staging in patients with endometrioid carcinomas. This is a retrospective analysis of 79 patients undergoing intraoperative FS and with endometrioid adenocarcinomas. Intraoperative pathological findings were compared with final results as to grade, depth of myometrial invasion (MI), cervical involvement, lymphovascular space invasion (LVSI) and stage. We also analyzed whether staging procedures like pelvic or para-aortic lymph node metastasis, peritoneal cytology and extension beyond of uterus were related to FS findings. Staging was based on the FIGO 2009. FS results were agreement in 89.9 % for grade, 88.6 % for depth of MI, 100 % for cervical invasion, and 92.4 % for LVSI, compared with PS. On FS, 12, 16.6 and 44.4 % of specimens in stages of IA, IB and II became upstaged in final pathology, respectively. Of 79 cases, 5 (6.3 %) were upstaged to IIIC1, and 3 (3.8 %) were upstaged to IIIC2 because of lymph node metastasis. A significant relationship was detected between lymph node metastasis, and FS grades (p = 0.001), LVSI (p = 0.000), cervical invasion (p = 0.006) and MI (p = 0.001). We consider that intraoperative FS is a useful procedure to identify poor prognostic pathological factors. While grading, depth of MI, cervical stromal invasion and LVSI on FS are significant in predicting lymph node metastasis, the existence of cervical stromal invasion and LVSI should be considered more effective parameters in the identification of metastatic endometrial cancer risks.en_US
dc.identifier.doi10.1007/s00404-015-3621-5en_US
dc.identifier.endpage397en_US
dc.identifier.issn0932-0067en_US
dc.identifier.issn1432-0711en_US
dc.identifier.issue2en_US
dc.identifier.pmid25608758en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage391en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00404-015-3621-5
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32652
dc.identifier.volume292en_US
dc.identifier.wosWOS:000355864000025en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofARCHIVES OF GYNECOLOGY AND OBSTETRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEndometrial canceren_US
dc.subjectFrozen sectionen_US
dc.subjectMyometrial invasionen_US
dc.subjectCervical stromal invasionen_US
dc.subjectLymphovascular invasionen_US
dc.subjectMetastasisen_US
dc.titleThe evaluation of reliability and contribution of frozen section pathology to staging endometrioid adenocarcinomasen_US
dc.typeArticleen_US

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