The influence of dexmedetomidine on ischemic rat hippocampus

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dc.contributor.authorEser, Olcay
dc.contributor.authorFidan, Huseyin
dc.contributor.authorSahin, Onder
dc.contributor.authorCosar, Murat
dc.contributor.authorYaman, Mehmet
dc.contributor.authorMollaoglu, Hakan
dc.contributor.authorSongur, Ahmet
dc.date.accessioned2020-03-26T17:28:10Z
dc.date.available2020-03-26T17:28:10Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn our study, we evaluated the neuroprotective effects of dexmedetomidine on oxidantantioxidant systems, pro -inflammatory cytokine TNF-a and number of apoptotic neurons on hippocampus and dentate gyrus after transient global cerebral I/R injury. Eighteen rats divided into 3 groups, equally. Group I rats were used as shams. For group II and III rats, they were prepared for transient global cerebral ischemia using a four-vessel- occlusion model. 5 mL/kg/h 0.9% sodium chloride was infused to the Group II and 3 Pg/kg/h/5 ml dexmedetomidine was infused to the Group III for 2 h after I/R injury. The levels of MDA and NO and activities of SOD and CAT were measured in the left hippocampus tissue. The levels of TNF-a concentration were measured in the plasma. The number of apoptotic neurons was counted by TUNNEL method in histological samples of right hippocampus tissue. MDA and NO levels increased in Group II compared with Group I rats (p=0.002, p=0.002, respectively). In group III, MDA and NO levels decreased as compared to Group 11 (p=0.015, p=0.002, respectively). SOD and CAT activities increased in Group III as compared to Group II rats (p = 0.002, p = 0.002, respectively). The decrease in TNF-a levels of group III was significant as compared to group II (p=0.016). The number of apoptotic neurons in group III was lower than Group II rats. Our study showed that dexinedetomidine has a neuroprotective effect on hippocampus and dentate gyrus of rats after transient global cerebral I/R injury. (c) 2008 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.brainres.2008.04.045en_US
dc.identifier.endpage256en_US
dc.identifier.issn0006-8993en_US
dc.identifier.issn1872-6240en_US
dc.identifier.pmid18514174en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage250en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.brainres.2008.04.045
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22728
dc.identifier.volume1218en_US
dc.identifier.wosWOS:000258016300024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofBRAIN RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcerebralen_US
dc.subjectdexmedetomidineen_US
dc.subjectinjuryen_US
dc.subjectischemia-reperfusionen_US
dc.subjecthippocampusen_US
dc.titleThe influence of dexmedetomidine on ischemic rat hippocampusen_US
dc.typeArticleen_US

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