The effectiveness of various doses of octreotide for sulfonylurea-induced hypoglycemia after overdose

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dc.contributor.authorGul, Mehmet
dc.contributor.authorCandler, Basar
dc.contributor.authorGirisgin, Sadik
dc.contributor.authorAyan, Murat
dc.contributor.authorKocak, Sedat
dc.contributor.authorUnlu, Ali
dc.date.accessioned2020-03-26T17:04:33Z
dc.date.available2020-03-26T17:04:33Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study was conducted to investigate the effectiveness of various doses of octreotide in reducing hypoglycemic attacks and the need for dextrose in patients with refractory and recurrent hypoglycemia related to sulfonylurea toxicity. This study was carried out at the Center of Experimental Research of Selcuk University Merann School of Medicine in Konya, Turkey. A total of 40 New Zealand rabbits of both sexes, weighing between 2500 and 3000 g, were used in this experiment. Rabbits were randomly divided into 4 groups, each of which consisted of 10 animals. All animals were given oral glidazide 100 mg. For the treatment of hypoglycemic attacks in group 1, only 15 mL of 50% dextrose (7.5 g) was given intravenously; in groups II, III, and IV, octreotide was given in doses of 25 mu g, 50 mu g, and 100 mu g, respectively. Octreotide was given to groups II, III, and IV at the 8th hour (when hypoglycemic attacks were induced), along with an intravenous infusion of an additional 15 mL of 50% dextrose (7.5 g) for each hypoglycemic attack that occurred. After the toxic dose was given, the rabbits were given the amount of dextrose used before and after octreotide administration, and the numbers of hypoglycemic attacks were recorded. The values of blood glucose for all animals were read every hour on the hour from the beginning of the study, and the study ended at the 24th hour, when hypoglycemic attacks stopped. A significant difference was observed between groups I, II, and IV in numbers of hypoglycemic attacks that occurred and dextrose doses given between 9 and 24 h (P=.001). The findings of this study suggest that a single dose of octreotide 100 mu g may be used to reduce the number of refractory and recurrent hypoglycemic attacks that occur because of sulfonylurea overdose; large prospective studies are needed to validate these findings.en_US
dc.identifier.doi10.1007/BF02850209en_US
dc.identifier.endpage884en_US
dc.identifier.issn0741-238Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid17276956en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage878en_US
dc.identifier.urihttps://dx.doi.org/10.1007/BF02850209
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20727
dc.identifier.volume23en_US
dc.identifier.wosWOS:000244518100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHEALTH COMMUNICATIONS INCen_US
dc.relation.ispartofADVANCES IN THERAPYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsulfonylureaen_US
dc.subjecthypoglycemic attacken_US
dc.subjectoctreotideen_US
dc.titleThe effectiveness of various doses of octreotide for sulfonylurea-induced hypoglycemia after overdoseen_US
dc.typeArticleen_US

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