Phenolic characterization, antioxidant activity, and enzyme inhibitory properties of berberis thunbergii DC. leaves: A valuable source of phenolic acids

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dc.contributor.authordel Pilar Fernandez-Poyatos, Maria
dc.contributor.authorRuiz-Medina, Antonio
dc.contributor.authorZengin, Gökhan
dc.contributor.authorLlorent-Martinez, Eulogio J.
dc.date.accessioned2020-03-26T20:19:08Z
dc.date.available2020-03-26T20:19:08Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractBerberis species are known for their use in traditional medicine. Here, we report the phenolic composition and bioactivity of methanolic and aqueous extracts of Berberis thunbergii DC. leaves. The phenolic profiling and the quantitation of the main compounds were performed by high-performance liquid chromatography with diode array and mass spectrometry detections. The most abundant compounds in both extracts were caffeoylquinic acids (chlorogenic acid, particularly, with a concentration of 90.1-101.3 mg g(-1) dried extract), followed by caffeoylglucaric acids and quercetin glycosides. Antioxidant and radical scavenging assays (phosphomolybdenum, DPPH, ABTS, CUPRAC, FRAP, metal chelating activity), as well as enzyme inhibitory assays (acetylcholinesterase, butyrylcholinesterase, tyrosinase, amylase, glucosidase, and lipase), were carried out to evaluate the potential bioactivity of B. thunbergii. The methanolic extract presented the highest antioxidant and radical scavenging values, in agreement with its higher phenolic content. Regarding enzyme inhibitory potential, the methanolic extract was also more potent than the aqueous one. Hence, B. thunbergii leaves represent a suitable candidate for the preparation of pharmaceutical or nutraceutical products.en_US
dc.description.sponsorshipMinisterio de Economia y CompetitividadSpanish Government [CTQ2016-7511-R]en_US
dc.description.sponsorshipThis study was funded by the Ministerio de Economia y Competitividad (grant number CTQ2016-7511-R).en_US
dc.identifier.citationdel Pilar Fernandez-Poyatos, M., Ruiz-Medina, A., Zengin, G., Llorent-Martinez, E. J. (2019). Phenolic Characterization, Antioxidant Activity, and Enzyme Inhibitory Properties of Berberis thunbergii DC. Leaves: A Valuable Source of Phenolic Acids. Molecules, 24,(22), 1-14.
dc.identifier.doi10.3390/molecules24224171en_US
dc.identifier.issn1420-3049en_US
dc.identifier.issue22en_US
dc.identifier.pmid31744256en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.3390/molecules24224171
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38093
dc.identifier.volume24en_US
dc.identifier.wosWOS:000501529700160en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMOLECULESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBerberis thunbergiien_US
dc.subjectchlorogenic aciden_US
dc.subjectcaffeoylquinic aciden_US
dc.subjectantioxidanten_US
dc.subjectenzyme inhibitionen_US
dc.subjectphytochemicalen_US
dc.subjectphenolicen_US
dc.titlePhenolic characterization, antioxidant activity, and enzyme inhibitory properties of berberis thunbergii DC. leaves: A valuable source of phenolic acidsen_US
dc.typeArticleen_US

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