Coenzyme Q10 supplementation and diastolic heart functions in hemodialysis patients: A randomized double-blind placebo-controlled trial

Basit Öğe Kaydı
dc.contributor.authorTurk, Suleyman
dc.contributor.authorBaki, Aysegul
dc.contributor.authorSolak, Yalcin
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorAtalay, Huseyin
dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorAribas, Alpay
dc.date.accessioned2020-03-26T18:41:18Z
dc.date.available2020-03-26T18:41:18Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCoenzyme Q10 (CoQ10) supplementation has been shown to improve diastolic heart function in various patient cohorts. Systolic and diastolic dysfunctions are common in patients with end-stage renal disease. Favorable effects of CoQ10 on cardiac functions are yet to be seen in hemodialysis patients. We aimed to evaluate effect of CoQ10 supplementation on diastolic function in a cohort of maintenance hemodialysis patients. This was a prospective, double-blind, placebo-controlled, crossover study in which all patients received placebo and oral CoQ10 200mg/d during the 8 weeks in each phase, with a 4-week washout period. Participants underwent conventional and tissue Doppler echocardiography before and after each study phase. Parameters characterizing left ventricle diastolic function and other standard echocardiographic measurements were recorded. Twenty-eight patients were randomized, but 22 patients completed study protocol. Intraventricular septum (IVS) thickness and left ventricle mass were significantly decreased in CoQ10 group (P=0.03 and P=0.01, respectively). Myocardial peak systolic and early diastolic velocities derived from IVS were significantly increased (P=0.048 and P=0.04, respectively). Isovolumetric relaxation time and E/Em ratio calculated for IVS also significantly reduced in CoQ10 group (p=0.02 and p=0.04, respectively). There was no significant difference in any of the studied echocardiographic parameters in placebo group. The results of this study showed that CoQ10 supplementation did not significantly improved diastolic heart functions compared with placebo in maintenance hemodialysis patients.en_US
dc.description.sponsorshipERA-EDTAen_US
dc.description.sponsorshipWe thank the staff of the private dialysis center, RTS Beyhekim, especially Dr Ismail Gultekin for his help with collection of data. Dr A. Gaipov received grant support from the ERA-EDTA fellowship program. No sources of funding were used to conduct this study or prepare this manuscript.en_US
dc.identifier.doi10.1111/hdi.12022en_US
dc.identifier.endpage381en_US
dc.identifier.issn1492-7535en_US
dc.identifier.issn1542-4758en_US
dc.identifier.issue3en_US
dc.identifier.pmid23360359en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage374en_US
dc.identifier.urihttps://dx.doi.org/10.1111/hdi.12022
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29305
dc.identifier.volume17en_US
dc.identifier.wosWOS:000320936600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofHEMODIALYSIS INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCoenzyme Q10en_US
dc.subjectdiastolic heart functionen_US
dc.subjecthemodialysisen_US
dc.subjectechocardiographyen_US
dc.titleCoenzyme Q10 supplementation and diastolic heart functions in hemodialysis patients: A randomized double-blind placebo-controlled trialen_US
dc.typeArticleen_US

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