Association of clinical androgen excess with radial artery intima media thickness in women with polycystic ovary syndrome

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dc.contributor.authorYilmaz, S. A.
dc.contributor.authorKebapcilar, A.
dc.contributor.authorKoplay, M.
dc.contributor.authorKerimoglu, O. S.
dc.contributor.authorPekin, A. T.
dc.contributor.authorGencoglu, B.
dc.contributor.authorDogan, N. U.
dc.date.accessioned2020-03-26T19:01:01Z
dc.date.available2020-03-26T19:01:01Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study explores the relationship between clinical cardiovascular risk factors and clinical androgen excess, with direct comparison to radial artery intima media thickness (rIMT). rIMT of 91 patients with polycystic ovary syndrome (PCOS) were compared with 72 healthy women. Patients were divided into three groups with regard to body mass index (BMI). Group1=56 women (31 controls and 25 PCOS) with low BMI(18-22.49 kg/m(2)), Group2=36 women (15 controls and 21 PCOS) with normal BMI (22.5-24.99 kg/m(2)) and Group3=71 women (26 controls and 45 PCOS) with high BMI (25-30 kg/m(2)). rIMT was significantly higher in patients with PCOS (p=0.007). rIMT was significantly higher group1 and group3 in patients with PCOS compared to controls (p=0.007 and p=0.042, respectively). There was a significant positive association between rIMT levels and fT in women with PCOS in group1 (r=0.24, p=0.04). rIMT levels correlated to fT levels in women with PCOS in group3 (r=0.32, p=0.03). Modified Ferriman-Gallwey (mFG) scores demonstrated a positive association with free testosterone, total testosterone, free androgen index, waist circumference (WC), LH levels, insulin levels, Homeostasis Model Assessment index(HOMA-IR), rIMT and a negative correlation with sex hormone binding globulin in group1 and group2. mFG scores demonstrated a positive association with free testosterone (r=0.33, p=0.029) in group3, but no association was found between mFG and WC, HOMA-IR in group3. Our findings indicate that clinical androgen excess may be associated with cardiovascular disease in patients with PCOS.en_US
dc.identifier.doi10.3109/09513590.2015.1014783en_US
dc.identifier.endpage482en_US
dc.identifier.issn0951-3590en_US
dc.identifier.issn1473-0766en_US
dc.identifier.issue6en_US
dc.identifier.pmid26213862en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage477en_US
dc.identifier.urihttps://dx.doi.org/10.3109/09513590.2015.1014783
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31874
dc.identifier.volume31en_US
dc.identifier.wosWOS:000359888500014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofGYNECOLOGICAL ENDOCRINOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAndrogenen_US
dc.subjectbody mass indexen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectintima media thicknessen_US
dc.subjectpolycystic ovary syndromeen_US
dc.titleAssociation of clinical androgen excess with radial artery intima media thickness in women with polycystic ovary syndromeen_US
dc.typeArticleen_US

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