The changes in biomarkers for necrotising enterocolitis in premature calves with respiratory distress syndrome

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dc.contributor.authorYıldız, Ramazan.
dc.contributor.authorOk, Mahmut.
dc.contributor.authorIder, Merve.
dc.contributor.authorAkar, Aybars.
dc.contributor.authorNaseri, Amir.
dc.contributor.authorKoral, Erman.
dc.date.accessioned2020-03-26T20:19:22Z
dc.date.available2020-03-26T20:19:22Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümüen_US
dc.description.abstractThe aim of this study was to determine the changes of the biomarkers used for the diagnosis of necrotising enterocolitis of human neonates in premature calves with respiratory distress syndrome (RDS). Novel biomarkers including the intestinal fatty acid binding protein (IFABP), the liver-type FABP (LFABP), trefoil factor-3 (TFF3), actin gamma 2 smooth muscle (ACTG2), and Claudin-3 were investigated using bovine specific ELISA kits. Thirty premature calves with respiratory distress syndrome (the RDS group), seven premature calves without RDS (the non-RDS group), and seven healthy calves (control) were included in the study. Blood samples from all the groups were taken at 0 and 48 h for the blood gas and biomarker measurement. It was determined that IFABP (P < 0.05), LFABP (P < 0.05), TFF3 (P < 0.05), ACTG2 (P < 0.05), and Claudin-3 (P < 0.05) in the control group were significantly higher than those in the RDS and non-RDS groups at 0 hour. The LFABP and Claudin-3 concentrations in the control group were statistically higher (P < 0.05) than those in the RDS and non-RDS groups at 48 h, whereas the ACTG2 and TFF3 contents were significantly higher (P < 0.05) than the non-RDS group. A significant increase in the contents of IFABP (P <= 0.01), LFABP (P < 0.05), TFF3 (P < 0.05), ACTG2 (P < 0.05) at 48 h was detected in the RDS group only. In conclusion, the changes in the biomarkers support the suspicion of intestinal damage such as necrotising enterocolitis (NEC) after enteral feeding in premature calves with RDS. Intestinal damage biomarkers such as IFABP, LFABP, TFF3, and ACTG2 may be useful in the diagnosis of intestinal damage in premature calves. These results also indicate that the plasma concentrations of the intestinal biomarkers change in new born calves with their gestational age.en_US
dc.description.sponsorshipSelcuk University, Scientific Research Project Office, Konya [16401150]en_US
dc.description.sponsorshipSupported by the Selcuk University, Scientific Research Project Office, Konya (Project No. 16401150).en_US
dc.identifier.citationYildiz, R., Ok, M., Ider, M., Akar, A., Naseri, A., Koral, E. (2019). The Changes in Biomarkers for Necrotising Enterocolitis in Premature Calves with Respiratory Distress Syndrome. Veterinarni Medicina, 64(10), 440-447.
dc.identifier.doi10.17221/37/2019-VETMEDen_US
dc.identifier.endpage447en_US
dc.identifier.issn0375-8427en_US
dc.identifier.issn1805-9392en_US
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage440en_US
dc.identifier.urihttps://dx.doi.org/10.17221/37/2019-VETMED
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38235
dc.identifier.volume64en_US
dc.identifier.wosWOS:000493122800003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorOk, Mahmut.
dc.institutionauthorIder, Merve.
dc.institutionauthorNaseri, Amir.
dc.institutionauthorKoral, Erman.
dc.language.isoenen_US
dc.publisherCZECH ACADEMY AGRICULTURAL SCIENCESen_US
dc.relation.ispartofVETERINARNI MEDICINAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectactinen_US
dc.subjectclaudinen_US
dc.subjectFABPen_US
dc.subjecthypoxiaen_US
dc.subjecttrefoil factoren_US
dc.titleThe changes in biomarkers for necrotising enterocolitis in premature calves with respiratory distress syndromeen_US
dc.typeArticleen_US

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