Experimental Evaluation of the Effects of Zoledronic Acid on Regenerate Bone Formation and Osteoporosis in Mandibular Distraction Osteogenesis

Basit Öğe Kaydı
dc.contributor.authorPampu, A. Alper
dc.contributor.authorDolanmaz, Doğan
dc.contributor.authorTüz, Hakan H.
dc.contributor.authorKarabacakoğlu, Aydın
dc.date.accessioned2020-03-26T17:03:33Z
dc.date.available2020-03-26T17:03:33Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to evaluate the effects of systemically administered zoledronic acid (ZA) on the bone mineral density (BMD) and bone mineral content (BMC) at mandibular distraction sites in rabbits. Materials and Methods: Eighteen New Zealand white rabbits were randomly divided into 2 groups. Bone lengthening was performed in the left portion of the mandible through distraction osteogenesis at a rate of 0.5 mm every 12 hours for 5 days. While the experimental group rabbits were administered intravenous 0.1 mg/kg ZA, control group rabbits were given only saline infusion during operation. All animals were sacrificed at the end of the consolidation period of 28 days. The mandibles of all animals were removed and both the anterior and posterior pin regions of the regenerate and regenerate region were evaluated by dual energy x-ray absorptiometry (DEXA). BMD and BMC data were statistically analyzed. Results: Except for 1 rabbit from the experimental group that had an infection at the external pin region, all animals showed complete clinical healing. When the values in the group receiving ZA were compared with those of the control group, it was observed that the BMD values of the anterior pin region of regenerate, regenerate region, and posterior pin region increased by 23%, 20%, and 31%, respectively; and BMC values increased by 22%, 24%, and 32%, respectively. When data of these regions were compared, both BMD and BMC were found statistically different in all regions (P <.05). Conclusion: Results of this study showed that ZA had positive effects on new bone formation at and around the distraction gaps of the lengthened rabbit mandibles by distraction osteogenesis.en_US
dc.identifier.citationPampu, A. A., Dolanmaz, D., Tüz, H. H., Karabacakoğlu, A., (2006). Experimental Evaluation of the Effects of Zoledronic Acid on Regenerate Bone Formation and Osteoporosis in Mandibular Distraction Osteogenesis. Journal of Oral and Maxillofacial Surgery, 64(8), 1232-1236. Doi:10.1016/j.joms.2006.04.038
dc.identifier.doi10.1016/j.joms.2006.04.038en_US
dc.identifier.endpage1236en_US
dc.identifier.issn0278-2391en_US
dc.identifier.issn1531-5053en_US
dc.identifier.issue8en_US
dc.identifier.pmid16860215en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1232en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.joms.2006.04.038
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20490
dc.identifier.volume64en_US
dc.identifier.wosWOS:000239549400010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorPampu, A. Alper
dc.institutionauthorDolanmaz, Doğan
dc.institutionauthorKarabacakoğlu, Aydın
dc.language.isoenen_US
dc.publisherW B Saunders Co-elsevier Incen_US
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleExperimental Evaluation of the Effects of Zoledronic Acid on Regenerate Bone Formation and Osteoporosis in Mandibular Distraction Osteogenesisen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
20490.pdf
Boyut:
144.78 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Ağız, Diş ve Çene Cerrahisi/Makale
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu