The neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhage

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dc.contributor.authorCosar, Murat
dc.contributor.authorEser, Olcay
dc.contributor.authorFidan, Huseyin
dc.contributor.authorSahin, Onder
dc.contributor.authorBuyukbas, Sadik
dc.contributor.authorEla, Yuksel
dc.contributor.authorYagmurca, Murat
dc.date.accessioned2020-03-26T17:40:48Z
dc.date.available2020-03-26T17:40:48Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Subarachnoid hemorrhage is a Serious Condition. often accompanied by cerebral vasospasm. which may lead to brain ischemia and neurologic deterioration. We evaluated if dexmedetomidine has neuroprotective effects in the hippocampus of vasospastic SAH rabbits or not. Materials and Methods: Eighteen New Zealand rabbits were taken. Ail experimental SAH model was Formed by injecting 0.9 mL of autologous arterial blood per 1 kg of body weight to the cisterna magna of 12 rabbits. Craniotomy was performed ill the control group (n = 6) except performing experimental SAH. Rabbits in the SAH-alone (n = 6) group were infused with 5 mL . kg(-1) . h(-1) 0.9% sodium chloride, and rabbits (n = 6) in the SAH-dexmedetomidine group were infused with 5 mu g . kg(-1) . h(-1) dexmedetomidine for 2 hours, 48 hours alter SAH was established. Rabbits of all groups were sacrificed via penthotal 24 hours after dexmedetomidine administration. Brains were removed immediately. and hippocampal tissues were blocked from the right hemisphere for histopathologic study. In addition to this, hippocampal tissues of left hemispheres were dissected for biochemical analyses to evaluate MDA levels, activity of XO, and SOD. Results: The histopathologic study showed that dexmedetomidine may have a neuroprotective effect in SAH-induced hippocampal injuries. The biochemical parameters Support the neuroprotective effect of dexmedetomidine (P < .05). Conclusion: Our Study showed that dexmedetomidine may have a neuroprotective effect ill the hippocampus of vasospastic SAH rabbits. (C) 2009 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.surneu.2007.08.020en_US
dc.identifier.endpage59en_US
dc.identifier.issn0090-3019en_US
dc.identifier.issue1en_US
dc.identifier.pmid18207556en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.surneu.2007.08.020
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23961
dc.identifier.volume71en_US
dc.identifier.wosWOS:000262098400009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofSURGICAL NEUROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBrain ischemiaen_US
dc.subjectDexmedetomidineen_US
dc.subjectNeuroprotectiveen_US
dc.subjectSubarachnoid hemorrhageen_US
dc.titleThe neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhageen_US
dc.typeArticleen_US

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