Investigation of Human Papillomavirus (HPV) and Epstein-Barr Virus (EBV) in antrochoanal polyps

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dc.contributor.authorYılmaz, Esra
dc.contributor.authorAlataş, Necat
dc.contributor.authorUçar, Fahri
dc.contributor.authorÇora, Tülin
dc.contributor.authorBuruk, Kurtuluş
dc.contributor.authorÜnlü, Yaşar
dc.date.accessioned2020-03-26T20:14:51Z
dc.date.available2020-03-26T20:14:51Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives/hypotheses: This study aimed to investigate the presence of HPV (HPV types 11 and 16) and EBV in antrochoanal polyps and to contribute to the current literature in this regard. Study design: A case-control study. Methods: A total of 100 patients (including 43 patients undergoing surgery for antrochoanal polyp, 27 patients undergoing surgery for nasal polyp, and 30 patients undergoing surgery for hypertrophic inferior turbinate) were included in this study. DNA was isolated from formalin-fixed, paraffin-embedded samples with the aid of the Bioneer's AccuPrep Genomic DNA Extraction Kit. In the obtained genomic DNAs, while the detection of HPV DNA was performed using the nested-PCR method, the detection of HPV types 11/16 and EBV DNA was performed using the RT-PCR method. Results: The mean age of the patients with antrochoanal polyp was 26.7 +/- 15.4 years (range 7-70). There were 20 (46.5%) women and 23 (53.5%) men in the antrochoanal polyp group. HPV DNA was positively detected using the nested-PCR method in 14 (32.6%) of the patients with antrochoanal polyp and in 3 (11.1%) of the patients with nasal polyp. HPV DNA was not detected in the hypertrophic inferior turbinate group (control group). There was a statistically significant difference between all groups in terms of HPV DNA positivity. In the antrochoanal polyp group, 2 patients had HPV 11 positivity and 12 patients had HPV 16 positivity. In the nasal polyp group, 1 patient had HPV 11 positivity and 2 patients had HPV 16 positivity. EBV DNA was positively detected in 16 (37.2%) of the patients with antrochoanal polyp, in 11 (40.7%) of the patients with nasal polyp and in 8 (26.7%) of the patients with hypertrophic inferior turbinate, respectively. There was no statistically significant difference between the groups in terms of EBV DNA positivity. Conclusions: This study demonstrates that there is a need for further studies investigating the presence of viruses in antrochoanal polyps.en_US
dc.description.sponsorshipEducational Planning Committee of Medical Sciences University Konya Training and Research Hospitalen_US
dc.description.sponsorshipThis study was supported by the fund of the Educational Planning Committee of Medical Sciences University Konya Training and Research Hospital.en_US
dc.identifier.citationYılmaz, E., Alatas, N., Ucar, F., Cora, T., Buruk, K., Unlu, Y. (2019). Investigation Of Human Papillomavirus (HPV) And Epstein-Barr Virus (EBV) İn Antrochoanal Polyps. American Journal Of Otolaryngology, 40,(3), 389-392.
dc.identifier.doi10.1016/j.amjoto.2019.02.008en_US
dc.identifier.endpage392en_US
dc.identifier.issn0196-0709en_US
dc.identifier.issn1532-818Xen_US
dc.identifier.issue3en_US
dc.identifier.pmid30808528en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage389en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.amjoto.2019.02.008
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37946
dc.identifier.volume40en_US
dc.identifier.wosWOS:000469307400010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCora, Tulin
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.relation.ispartofAMERICAN JOURNAL OF OTOLARYNGOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntrochoanal polypen_US
dc.subjectHPVen_US
dc.subjectEBVen_US
dc.subjectRT-PCRen_US
dc.titleInvestigation of Human Papillomavirus (HPV) and Epstein-Barr Virus (EBV) in antrochoanal polypsen_US
dc.typeArticleen_US

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