Long-term isotretinoin use does not cause parenchymal liver change: Ultrasonographic study in 50 patients

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dc.contributor.authorAktaş, Habibullah
dc.contributor.authorErtuğrul, Göksen
dc.contributor.authorParlak, Muharrem
dc.contributor.authorÜnal, Mehmet
dc.date.accessioned2020-03-26T20:15:05Z
dc.date.available2020-03-26T20:15:05Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe effect of isotretinoin on liver enzymes and lipid profile is reported as rare and reversible. However, possible parenchymal liver changes have not been demonstrated so far. The aim of this study was to evaluate the ultrasonography findings of the liver in patients receiving long-term isotretinoin therapy. We examined ultrasonographic findings of the liver together with serum alanin aminotransferase (ALT), aspartate aminotransferase (AST), and total cholesterol and triglyceride levels in 50 consecutive patients who have taken isotretinoin 10-40 mg daily for at least 6 months between January and December 2017. Of 50 patients examined, 40 were female, 10 were male. Mean age of the patients was 24.8 years. Five patients aged between 42 and 62 were found to have Grade 1 hepatosteatosis. Despite a moderate elevation, serum ALT, AST, and total cholesterol and triglyceride levels were in normal range in these five patients. Moreover, one patient had elevated ALT, and one another patient had elevated triglyceride level although both have normal liver ultrasonographic findings. Isotretinoin did not cause parenchymal liver changes as well as serum ALT, AST, and total cholesterol and triglyceride levels in patients who take it 10-40 mg daily for at least 6 months.en_US
dc.identifier.citationAktas, H., Ertugrul, G., Parlak, M., Unal, M. (2019). Long‐Term İsotretinoin Use Does Not Cause Parenchymal Liver Change: Ultrasonographic Study İn 50 Patients. Dermatologic Therapy, 32,(5), E13012.
dc.identifier.doi10.1111/dth.13012en_US
dc.identifier.issn1396-0296en_US
dc.identifier.issn1529-8019en_US
dc.identifier.issue5en_US
dc.identifier.pmid31241229en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1111/dth.13012
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37981
dc.identifier.volume32en_US
dc.identifier.wosWOS:000474169700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUnal, Mehmet
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofDERMATOLOGIC THERAPYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectacneen_US
dc.subjectisotretinoinen_US
dc.subjectliveren_US
dc.titleLong-term isotretinoin use does not cause parenchymal liver change: Ultrasonographic study in 50 patientsen_US
dc.typeArticleen_US

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