Radiotherapy in the management of Kaposi's sarcoma: Comparison of 8 Gy versus 6 Gy

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dc.contributor.authorYildiz, Ferah
dc.contributor.authorGenc, Mine
dc.contributor.authorAkyurek, Serap
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorOzyar, Enis
dc.contributor.authorSelek, Ugur
dc.contributor.authorAtahan, I. Lale
dc.date.accessioned2020-03-26T17:04:08Z
dc.date.available2020-03-26T17:04:08Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To evaluate prospectively the efficacy of a single fraction of high-dose radiotherapy in patients with Kaposi's sarcoma. Patients: Between 1994 and 2004, 47 patients with Kaposi's sarcoma were treated at Hacettepe University, Department of Radiation Oncology. Thirteen (28%) patients received chemotherapy before radiotherapy and were referred due to recurrent or progressive disease or intolerance to chemotherapy. All lesions were treated locally with a 2-3-cm safety margin with 4-6-MeV electron beams. Radiotherapy consisted of a single fraction of 8 Gy in the first four years and 6 Gy thereafter. Results: The male:female ratio was 4:1. The median age was 61 years (range 18-87). Eight out of 47 patients (17%) had an underlying immunocompromised state, and one had a previous diagnosis of Hodgkin's disease. Of 203 fields treated, 51 and 152 fields were treated with 8 Gy and 6 Gy, respectively. Overall response rates (RR) at 12 months for 8- and 6 Gy were 93% and 86%, which were not statistically different. However, the difference between complete RRs at 12 months (93% and 60% for 8 Gy and 6 Gy respectively) was significant (p < 0.0001). Progression-free survival and reirradiation rates were not significantly different. Side effects were tolerable in all but three patients with grade 2-3 fibrosis and edema. Conclusion: Radiotherapy is an effective mode of treatment for Koposi's sarcoma, and a single dose of 8 Gy is more effective in terms of complete RR compared to 6 Gy, though overall response and progression-free survival rates were similar.en_US
dc.identifier.endpage1139en_US
dc.identifier.issn0027-9684en_US
dc.identifier.issue7en_US
dc.identifier.pmid16895284en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1136en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20636
dc.identifier.volume98en_US
dc.identifier.wosWOS:000239195600012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNATL MED ASSOCen_US
dc.relation.ispartofJOURNAL OF THE NATIONAL MEDICAL ASSOCIATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectKaposi's sarcomaen_US
dc.subjectradiotherapyen_US
dc.subjectsingle fractionen_US
dc.titleRadiotherapy in the management of Kaposi's sarcoma: Comparison of 8 Gy versus 6 Gyen_US
dc.typeArticleen_US

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