Effect of flunixin meglumine on cytokine levels in experimental Endotoxemia in mice

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dc.contributor.authorYazar, E.
dc.contributor.authorEr, A.
dc.contributor.authorUney, K.
dc.contributor.authorAltunok, V.
dc.contributor.authorElmas, M.
dc.date.accessioned2020-03-26T17:17:17Z
dc.date.available2020-03-26T17:17:17Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, effect of flunixin meglumine on serum tumour necrosis factor alpha, (TNF alpha) interleukin-1 beta and interleukin-10 levels was investigated in lipopolysaccharide-induced endotoxic mice. Healthy 273 Balb/C mice were used and divided into three equal groups. Group 1 was injected lipopolysaccharide (Escherichia coli 0 111:134, 250 mu g/mouse, intraperitoneally), Group 2 was injected flunixin meglumine (2.5 mg/kg, subcutaneously), and Group 3 was injected lipopolysaccharide + flunixin meglumine. After the treatments, at 0., 1., 2., 3., 6., 12., 24th hours and 3., 5., 7. 14., 21., 28th days blood samples were taken from seven mice in each group. Serum TNF alpha, interleukin-1 beta and interleukin-10 levels were measured using commercially available kits by enzyme-linked immunoassay. Flunixin meglumine did not affect the cytokine levels in healthy animals. While lipopolysaccharide increased serum TNF alpha, interleukin-1 beta and interleukin-10 levels, flunixin meglumine inhibited increases at levels of all cytokines. As result, flunixin meglumine showed depressor effect on cytokine levels in endotoxemia and the effect may be a reason for the first chosen member of nonsteroid anti-inflammatory drug in endotoxemia.en_US
dc.identifier.doi10.1111/j.1439-0442.2007.00959.xen_US
dc.identifier.endpage355en_US
dc.identifier.issn0931-184Xen_US
dc.identifier.issue7en_US
dc.identifier.pmid17718807en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage352en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1439-0442.2007.00959.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21339
dc.identifier.volume54en_US
dc.identifier.wosWOS:000249371600004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEffect of flunixin meglumine on cytokine levels in experimental Endotoxemia in miceen_US
dc.typeArticleen_US

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