Short-term thyroxine administration leads to lipid peroxidation in renal and testicular tissues of rats with hypothyroidism

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dc.contributor.authorMogulkoc, R
dc.contributor.authorBaltaci, AK
dc.contributor.authorOztekin, E
dc.contributor.authorOzturk, A
dc.contributor.authorSivrikaya, A
dc.date.accessioned2020-03-26T16:57:56Z
dc.date.available2020-03-26T16:57:56Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThyroid dysfunction brings about pathological changes in different organs of the body. The aim of the present study was to examine how experimental hypothyroidism and additional short-term high-dose thyroxine administration (one-week) affected lipid peroxidation in renal and testicular tissues of rats. The study was carried out on 30 male Spraque-Dawley rats. The experimental animals were divided into 3 groups as control, hypothyroidism and hypothyroidism + thyroxine administration. Both malondialdehyde (MDA) and glutathione (GSH) levels were lower in renal and testicular tissues of the hypothyroidism group than the control and hypothyroidism + thyroxine administration groups and the levels in hypothyroidism + thyroxine administration group were higher than those in the control and hypothyroidism groups (p < 0.001). Results of the study demonstrate that hypothyroidism reduced oxidant stress in kidney and testis tissues, but short-term, high-dose thyroxine administration in addition to hypothyroidism increased oxidant stress in the same tissues of rats.en_US
dc.identifier.doi10.1556/ABiol.56.2005.3-4.6en_US
dc.identifier.endpage232en_US
dc.identifier.issn0236-5383en_US
dc.identifier.issue03.04.2020en_US
dc.identifier.pmid16196198en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage225en_US
dc.identifier.urihttps://dx.doi.org/10.1556/ABiol.56.2005.3-4.6
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19873
dc.identifier.volume56en_US
dc.identifier.wosWOS:000231917900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAKADEMIAI KIADOen_US
dc.relation.ispartofACTA BIOLOGICA HUNGARICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthypothyroidismen_US
dc.subjectthyroxine administrationen_US
dc.subjectoxidant stressen_US
dc.subjectraten_US
dc.titleShort-term thyroxine administration leads to lipid peroxidation in renal and testicular tissues of rats with hypothyroidismen_US
dc.typeArticleen_US

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