Evaluation of acute phase proteins, some cytokines and hemostatic parameters in dogs with sepsis

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dc.contributor.authorOk, Mahmut
dc.contributor.authorEr, Cenk
dc.contributor.authorYildiz, Ramazan
dc.contributor.authorCol, Ramazan
dc.contributor.authorAydogdu, Ugur
dc.contributor.authorSen, Ismail
dc.contributor.authorGuzelbektes, Hasan
dc.date.accessioned2020-03-26T19:05:56Z
dc.date.available2020-03-26T19:05:56Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümüen_US
dc.description.abstractThe aim of this study was to evaluate the alterations in acute phase proteins, cytokines and hemostatic parameters in dogs with sepsis and to determine the importance of these parameters in diagnosis of the sepsis. Thirty dogs with sepsis and 9 healthy dogs were used in this study. Anorexia, depression, lethargy, hyperthermia, tachycardia, tachypnea, congestion in the mucosal membranes, prolonged capillary refill time, and leukocytosis or leucopenia were identified in the dogs with sepsis. The serum interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), interferon gamma (INF-gamma), C-reactive protein (CRP), serum amyloid A (SAA), prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (AT III), fibrinogen, protein C (PC), and D-dimer levels were measured in all dogs. We found that the serum IL-1 beta, TNF-alpha, INF-gamma, CRP and SAA concentrations were significantly elevated in dogs with sepsis as compared with healthy controls. In addition, the plasma PT and APTT levels were notably prolonged, the plasma fibrinogen, D-dimers and protein C concentrations were significantly increased. However, the antithrombin III activity was significantly decreased in the dogs with sepsis. In conclusion, the results of this study indicate that the SAA, IL-1 beta and TNF-alpha parameters play important roles in the inflammatory process in dogs with sepsis. The hemostatic abnormalities observed in dogs with sepsis may be due to the development of disseminated intravascular coagulation (DIC).en_US
dc.identifier.citationOk, M., Er, C., Yıldız, R., Çöl, R., Aydoğdu, U., Şen, İ., Güzelbekteş, H. (2015). Evaluation of Acute Phase Proteins, Some Cytokines and Hemostatic Parameters in Dogs with Sepsis. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 21(5), 761-766.
dc.identifier.doi10.9775/kvfd.2015.13418en_US
dc.identifier.endpage766en_US
dc.identifier.issn1300-6045en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage761en_US
dc.identifier.urihttps://dx.doi.org/10.9775/kvfd.2015.13418
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32119
dc.identifier.volume21en_US
dc.identifier.wosWOS:000362666900020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorOk, Mahmut
dc.institutionauthorEr, Cenk
dc.institutionauthorCol, Ramazan
dc.institutionauthorSen, Ismail
dc.institutionauthorGuzelbektes, Hasan
dc.language.isoenen_US
dc.publisherKAFKAS UNIV, VETERINER FAKULTESI DERGISIen_US
dc.relation.ispartofKAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDogsen_US
dc.subjectSepsisen_US
dc.subjectAcute phase proteinen_US
dc.subjectCytokinesen_US
dc.subjectCoagulation profileen_US
dc.titleEvaluation of acute phase proteins, some cytokines and hemostatic parameters in dogs with sepsisen_US
dc.typeArticleen_US

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